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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Coffee consumption and liver-related hospitalizations and deaths in the ARIC study
European journal of clinical nutrition, v 73(8), pp 1133-1140
01 Aug 2019
PMID: 30341433
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Coffee consumption has been found to be associated with reduced risk of chronic conditions such as liver disease. However, less is known about the association between coffee and liver-related hospitalizations and deaths.
We conducted a prospective analysis on 14,208 participants aged 45-64 years from the Atherosclerosis Risk in Communities (ARIC) study. Coffee consumption (cups/day) was assessed using food frequency questionnaires at visit 1 (1987-89) and visit 3 (1993-95). Liver-related hospitalizations were defined as a hospitalization with any International Classification of Diseases, Ninth Revision (ICD-9) code related to liver disease identified through cohort surveillance. Liver-related death was defined as any death with a liver disease ICD-9 code listed anywhere on the death certificate form.
There were 833 incident cases of liver-related hospitalizations over a median follow-up of 24 years and 152 liver-related deaths over a median follow-up of 25 years. Participants who were in the highest category of coffee consumption (≥ 3 cups/day) were more likely to be men, whites, current smokers, and current alcohol drinkers. In our fully adjusted model, consuming ≥ 3 cups/day of coffee was significantly associated with a reduced risk of liver-related hospitalizations compared with never drinkers (hazard ratio: 0.79, 95% CI: 0.63-0.99). There were no significant associations between coffee consumption and liver-related deaths after adjusting for covariates.
Coffee drinkers may be at lower risk for liver-related hospitalizations. This supports current evidence that low and moderate levels of coffee may be protective to the liver.
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Details
- Title
- Coffee consumption and liver-related hospitalizations and deaths in the ARIC study
- Creators
- Emily A Hu - Welch FoundationMariana Lazo - Johns Hopkins UniversityElizabeth Selvin - Johns Hopkins UniversityJames P Hamilton - Johns Hopkins University School of MedicineMorgan E Grams - Johns Hopkins University School of MedicineLyn M Steffen - University of MinnesotaJosef Coresh - Johns Hopkins MedicineCasey M Rebholz - Johns Hopkins University
- Publication Details
- European journal of clinical nutrition, v 73(8), pp 1133-1140
- Publisher
- Springer Nature
- Grant note
- T32 HL007024 / NHLBI NIH HHS HHSN268201700004I / NHLBI NIH HHS HHSN268201700005I / NHLBI NIH HHS K01 DK107782 / NIDDK NIH HHS HHSN268201700002I / NHLBI NIH HHS HHSN268201700003I / NHLBI NIH HHS HHSN268201700001I / NHLBI NIH HHS R01 DK089174 / NIDDK NIH HHS K24 DK106414 / NIDDK NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative
- Web of Science ID
- WOS:000479120900007
- Scopus ID
- 2-s2.0-85055268766
- Other Identifier
- 991020550490104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Nutrition & Dietetics