Journal article
Cognitive Correlates of Hippocampal Atrophy and Ventricular Enlargement in Adults with or without Mild Cognitive Impairment
Dementia and geriatric cognitive disorders extra, v 9(2), pp 281-293
01 May 2019
PMID: 31572424
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
We analyzed structural magnetic resonance imaging data from 58 cognitively normal and 101 mild cognitive impairment subjects. We used a general linear regression model to study the association between cognitive performance with hippocampal atrophy and ventricular enlargement using the radial distance method.Bilateral hippocampal atrophy was associated with baseline and longitudinal memory performance. Left hippocampal atrophy predicted longitudinal decline in visuospatial function. The multidomain ventricular analysis did not reveal any significant predictors.
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Details
- Title
- Cognitive Correlates of Hippocampal Atrophy and Ventricular Enlargement in Adults with or without Mild Cognitive Impairment
- Creators
- Naira Goukasian - University of VermontShai Porat - University of Southern CaliforniaAnna Blanken - University of Southern CaliforniaDavid Avila - University of California, IrvineDimitar Zlatev - Massachusetts General HospitalSona Hurtz - Drexel Univ, Coll Med, Philadelphia, PA 19104 USAKristy S. Hwang - Emory UniversityJonathan Pierce - University of California, Los AngelesShantanu H. Joshi - International Advanced Research Centre for Powder Metallurgy and New MaterialsEllen Woo - University of California, Los AngelesLiana G. Apostolova - Indiana University School of Medicine
- Publication Details
- Dementia and geriatric cognitive disorders extra, v 9(2), pp 281-293
- Publisher
- Karger
- Number of pages
- 13
- Grant note
- Easton Consortium for Alzheimer's Drug Discovery and Biomarker Development R01 AG040770; K02 AG048240; P50 AG16570; P30 AG010133; U01AG024904 / NIA; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine
- Web of Science ID
- WOS:000496485700008
- Scopus ID
- 2-s2.0-85071053090
- Other Identifier
- 991021860697404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Clinical Neurology