Journal article
Cognitive Effects of Adenotonsillectomy for Obstructive Sleep Apnea
Pediatrics (Evanston), v 138(2), pp 1-1
Aug 2016
PMID: 27464674
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Research reveals mixed evidence for the effects of adenotonsillectomy (AT) on cognitive tests in children with obstructive sleep apnea syndrome (OSAS). The primary aim of the study was to investigate effects of AT on cognitive test scores in the randomized Childhood Adenotonsillectomy Trial.
Children ages 5 to 9 years with OSAS without prolonged oxyhemoglobin desaturation were randomly assigned to watchful waiting with supportive care (n = 227) or early AT (eAT, n = 226). Neuropsychological tests were administered before the intervention and 7 months after the intervention. Mixed model analysis compared the groups on changes in test scores across follow-up, and regression analysis examined associations of these changes in the eAT group with changes in sleep measures.
Mean test scores were within the average range for both groups. Scores improved significantly (P < .05) more across follow-up for the eAT group than for the watchful waiting group. These differences were found only on measures of nonverbal reasoning, fine motor skills, and selective attention and had small effects sizes (Cohen's d, 0.20-0.24). As additional evidence for AT-related effects on scores, gains in test scores for the eAT group were associated with improvements in sleep measures.
Small and selective effects of AT were observed on cognitive tests in children with OSAS without prolonged desaturation. Relative to evidence from Childhood Adenotonsillectomy Trial for larger effects of surgery on sleep, behavior, and quality of life, AT may have limited benefits in reversing any cognitive effects of OSAS, or these benefits may require more extended follow-up to become manifest.
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Details
- Title
- Cognitive Effects of Adenotonsillectomy for Obstructive Sleep Apnea
- Creators
- H Gerry Taylor - Rainbow Babies & Children's HospitalSusan R Bowen - Rainbow Babies & Children's HospitalDean W Beebe - Cincinnati Children's Hospital Medical CenterElise Hodges - Departments of Psychiatry and Psychology, andRaouf Amin - Cincinnati Children's Hospital Medical CenterRaanan Arens - Children's Hospital at MontefioreRonald D Chervin - University of MichiganSusan L Garetz - University of MichiganEliot S Katz - Boston Children's HospitalReneé H Moore - Emory UniversityKnashawn H Morales - University of PennsylvaniaHiren Muzumdar - Children's Hospital of PittsburghShalini Paruthi - Cardinal Glennon Children’s Medical CenterCarol L Rosen - Rainbow Babies & Children's HospitalAnjali Sadhwani - Boston Children's HospitalNina Hattiangadi Thomas - Department of Child and Adolescent Psychiatry and Behavioral Sciences, Neuropsychology and Assessment Group, andJanice Ware - Boston Children's HospitalCarole L Marcus - Children's Hospital of PhiladelphiaSusan S Ellenberg - University of PennsylvaniaSusan Redline - Beth Israel Deaconess Medical CenterBruno Giordani - Departments of Psychiatry and Psychology, and
- Publication Details
- Pediatrics (Evanston), v 138(2), pp 1-1
- Grant note
- U01 HL083075 / NHLBI NIH HHS UL1 RR024134 / NCRR NIH HHS UL1 RR024989 / NCRR NIH HHS U01 HL083129 / NHLBI NIH HHS UL1 TR000003 / NCATS NIH HHS UL1 TR001073 / NCATS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:000381002500023
- Scopus ID
- 2-s2.0-84982815534
- Other Identifier
- 991021448187404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Pediatrics