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Cognitive Status, Stroke Symptom Reports, and Modifiable Risk Factors Among Individuals With No Diagnosis of Stroke or Transient Ischemic Attack in the RE asons for G eographic and R acial D ifferences in S troke (REGARDS) Study
Journal article   Open access   Peer reviewed

Cognitive Status, Stroke Symptom Reports, and Modifiable Risk Factors Among Individuals With No Diagnosis of Stroke or Transient Ischemic Attack in the RE asons for G eographic and R acial D ifferences in S troke (REGARDS) Study

Virginia G. Wadley, Leslie A. McClure, Virginia J. Howard, Frederick W. Unverzagt, Rodney C. Go, Claudia S. Moy, Martha R. Crowther, Camilo R. Gomez and George Howard
Stroke (1970), v 38(4), pp 1143-1147
Apr 2007
DOI: https://doi.org/10.1161/01.STR.0000259676.75552.38
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.1161/01.str.0000259676.75552.38View
Published, Version of Record (VoR)Maybe Open Access (Publisher Bronze),  Open
url
https://doi.org/10.1161/01.STR.0000259676.75552.38View
Published, Version of Record (VoR) Open

Abstract

Background and Purpose— Vascular disorders that increase risk for stroke may be accompanied by decrements in cognitive functioning and by stroke symptoms in the absence of diagnosed stroke or transient ischemic attack. This study evaluates relationships among cognitive status, stroke symptom reports, and cardiovascular and behavioral factors. Methods— RE asons for G eographic and R acial D ifferences in S troke (REGARDS), a prospective population study of stroke incidence, assesses stroke risk with telephone interviews and in-home physicals. Excluding subjects with a history of stroke or transient ischemic attack, this analysis includes 14 566 black and white men and women ≥45 years of age. Incremental logistic models examine baseline relationships among cognitive status (Six-item Screener scores), stroke symptom reports, demographics, health behaviors, cardiovascular indices, and depressive symptoms. Results— A history of stroke symptoms was related to impaired cognitive status after adjusting for age, gender, race, and education but not after adjusting for poor health behaviors, vascular risk factors, and depressive symptoms. Odds of experiencing a stroke symptom increased 35% with each of five modifiable factors (hypertension, diabetes, smoking, lack of exercise, depressive symptoms), and odds of cognitive impairment increased an additional 12% with each modifiable factor. Lifelong abstinence from alcohol, lack of exercise, and depressive symptoms were independently related to impaired cognitive status. Conclusions— The increased likelihood of cognitive impairment among subjects reporting stroke symptoms in the absence of a diagnosed stroke or transient ischemic attack suggests that such symptoms are not benign and may warrant clinical evaluation that includes a cognitive assessment. Future studies that include brain imaging may clarify the etiology of these symptoms.

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59 citations in Web of Science
62 citations in Scopus

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UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

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Collaboration types
Domestic collaboration
Web of Science research areas
Clinical Neurology
Peripheral Vascular Disease
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