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Journal article
Cognitive and Self-regulatory Mechanisms of Obesity Study (COSMOS): Study protocol for a randomized controlled weight loss trial examining change in biomarkers, cognition, and self-regulation across two behavioral treatments
Contemporary clinical trials, v 66
Mar 2018
PMID: 29274893
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Obesity is a global epidemic, yet successful interventions are rare. Up to 60% of people fail to achieve clinically meaningful, short-term weight loss (5–10% of start weight), whereas up to 72% are unsuccessful at achieving long-term weight loss (5–10% loss for ≥5years). Understanding how biological, cognitive, and self-regulatory factors work together to promote or to impede weight loss is clearly needed to optimize obesity treatment. This paper describes the methodology of the Cognitive and Self-regulatory Mechanisms of Obesity Study (the COSMOS trial). COSMOS is the first randomized controlled trial to investigate how changes in multiple biopsychosocial and cognitive factors relate to weight loss and one another across two weight loss treatments. The specific aims are to: 1) Confirm that baseline obesity-related physiological dysregulation is linked to cognitive deficits and poorer self-regulation, 2) Evaluate pre- to post-treatment change across time to assess individual differences in biomarkers, cognition, and self-regulation, and 3) Evaluate whether the acceptance-based treatment (ABT) group has greater improvements in outcomes (e.g., greater weight loss and less weight regain, improvements in biomarkers, cognition, and self-regulation), than the standard behavioral treatment group (SBT) from pre- to post-treatment and 1-year follow-up. The results of COSMOS will provide critical information about how dysregulation in biomarkers, cognition, and/or self-regulation is related to weight loss and whether weight loss treatments are differentially associated with these factors. This information will be used to identify promising treatment targets that are informed by biological, cognitive, and self-regulatory factors in order to advance obesity treatment.
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Details
- Title
- Cognitive and Self-regulatory Mechanisms of Obesity Study (COSMOS): Study protocol for a randomized controlled weight loss trial examining change in biomarkers, cognition, and self-regulation across two behavioral treatments
- Creators
- M.A.W. Hawkins - Oklahoma State University*Janna Colaizzi - Oklahoma State UniversityJohn Gunstad - Kent State UniversityJoel W. Hughes - Kent State UniversityLarry L. Mullins - Oklahoma State UniversityNancy Betts - Oklahoma State UniversityCaitlin E. Smith - Oklahoma State UniversityNatalie G. Keirns - Oklahoma State UniversityKathleen D. Vohs - University of MinnesotaShirley M. Moore - Case Western Reserve UniversityEvan M. Forman - Drexel UniversityWilliam R. Lovallo - Department of Veterans Affairs
- Publication Details
- Contemporary clinical trials, v 66
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Center for Weight, Eating and Lifestyle Science (WELL) [Historical]
- Web of Science ID
- WOS:000428105000003
- Scopus ID
- 2-s2.0-85041465959
- Other Identifier
- 991019169624304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Medicine, Research & Experimental
- Pharmacology & Pharmacy