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Journal article
Cognitive performance following lacunar stroke in Spanish-speaking patients: results from the SPS3 trial
International journal of stroke, v 10(4), pp 519-528
01 Jun 2015
PMID: 25973704
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
BackgroundCognitive impairment is frequent in lacunar stroke patients. The prevalence and pattern among Spanish-speaking patients are unknown and have not been compared across regions or with English-speaking patients.
AimsThe aim of this study was to characterize cognitive impairment in Spanish-speaking patients and compare it with English-speaking patients.
MethodsThe baseline neuropsychological test performance and the prevalence of mild cognitive impairment, defined as a z-score -15 on memory and/or non-memory tests, were evaluated in Spanish-speaking patients in the Secondary Prevention of Small Subcortical Strokes trial.
ResultsOut of 3020 participants, 1177 were Spanish-speaking patients residing in Latin America (n=693), the United States (n=121), and Spain (n=363). Low education (zero- to eight-years) was frequent in Spanish-speaking patients (49-57%). Latin American Spanish-speaking patients had frequent post-stroke upper extremity motor impairment (83%). Compared with English-speaking patients, all Spanish-speaking patient groups had smaller memory deficits and larger non-memory/motor deficits, with Latin American Spanish-speaking patients showing the largest deficits median z-score -13 to -06 non-memory tests; 50 for Grooved Pegboard; -07 to -03 for memory tests). The prevalence of mild cognitive impairment was high and comparable with English-speaking patients in the United States and Latin American Spanish-speaking patients but not the Spanish group: English-speaking patients=47%, Latin American Spanish-speaking patients=51%, US Spanish-speaking patients=40%, Spanish Spanish-speaking patients=29%, with >50% characterized as non-amnestic in Spanish-speaking patient groups. Older age [odds ratio per 10 years=152, confidence interval=135-171), lower education (odds ratio 0-4 years=123, confidence interval=090-167), being a Latin American resident (odds ratio=131, confidence interval=087-198), and post-stroke disability (odds ratio Barthel Index <95=189, confidence interval=143-250) were independently associated with mild cognitive impairment.
ConclusionsMild cognitive impairment in Secondary Prevention of Small Subcortical Strokes Spanish-speaking patients with recent lacunar stroke is highly prevalent but has a different pattern to that observed in English-speaking patients. A combination of socio-demographics, stroke biology, and stroke care may account for these differences.
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Details
- Title
- Cognitive performance following lacunar stroke in Spanish-speaking patients: results from the SPS3 trial
- Creators
- Claudia Jacova - Pacific University OregonLesly A. Pearce - Biostatistical Consultant, Minot, ND, USA.Ana M. Roldan - The University of Texas Health Science Center at HoustonAntonio Arauz - Neurology and Neurosurgery National Institute, Mexico City, Mexico.Jorge Tapia - Department of Neurology Catholic University Santiago ChileRaymond Costello - The University of Texas Health Science Center at San AntonioLeslie A. McClure - University of Alabama at BirminghamRobert G. Hart - McMaster UniversityOscar R. Benavente - Pacific University Oregon
- Publication Details
- International journal of stroke, v 10(4), pp 519-528
- Publisher
- Sage
- Number of pages
- 10
- Grant note
- National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA U01NS038529 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) U01-NS38529-04A1 / National Institutes of Neurological Disorders and Stroke (NIH-NINDS) of US Cooperative agreement Alzheimer Society of BC Professorship in Alzheimer's Research Endowment Fund
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:000354494000021
- Scopus ID
- 2-s2.0-84929335401
- Other Identifier
- 991019231656304721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Clinical Neurology
- Peripheral Vascular Disease