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Journal article
Cognitive tests aid in clinical differentiation of Alzheimer's disease versus Alzheimer's disease with Lewy body disease: Evidence from a pathological study
Alzheimer's & dementia, v 16(8), pp 1173-1181
Aug 2020
PMID: 32558217
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Introduction: Clinical differentiation between Alzheimer's disease (AD) and AD with Lewy body disease (LBD) is relatively imprecise. The current study examined pathologically confirmed group differences in neuropsychological functioning, and the classification ability of specific tests. Methods: Fifty-one participants with postmortem diagnoses of AD (n = 34) and AD plus LBD (n = 17) were drawn from the Predictors Study. One-way analyses of variance (ANOVAs) andx chi(2) analyses examined group differences in neuropsychological performance. Binary logistic regressions examined predictive utility of specific tests for pathological diagnosis. Results: Individuals with AD had better visuoconstruction (P= .006), phonemic fluency (P= .08), and processing speed than AD plus LBD (P = .013). No differences were found in memory, naming, semantic fluency, or set-switching. Processing speed and visuoconstruction predicted pathologic group (P = .03). Discussion: Processing speed and visuoconstruction predicted postmortem diagnosis of AD versus AD plus LBD. Current results offer guidance in the selection and interpretation of neuropsychological tests to be used in the differential diagnosis of early dementia.
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Details
- Title
- Cognitive tests aid in clinical differentiation of Alzheimer's disease versus Alzheimer's disease with Lewy body disease: Evidence from a pathological study
- Creators
- Martina Azar - Drexel University, Psychological and Brain Sciences (Psychology)Silvia Chapman - Columbia UniversityYian Gu - Columbia University Irving Medical CenterJames B. Leverenz - Cleveland Clin Fdn, Lou Ruvo Ctr Brain Hlth, Neurol Inst, 9500 Euclid Ave, Cleveland, OH 44195 USAYaakov Stern - Columbia University Irving Medical CenterStephanie Cosentino - Columbia University
- Publication Details
- Alzheimer's & dementia, v 16(8), pp 1173-1181
- Publisher
- Wiley
- Number of pages
- 9
- Grant note
- NIA, Grant/Award Number: R01AG007370
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychological and Brain Sciences (Psychology)
- Web of Science ID
- WOS:000577872500008
- Scopus ID
- 2-s2.0-85087167544
- Other Identifier
- 991021860683304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Clinical Neurology