Journal article
Cold physical plasma selects for specific T helper cell subsets with distinct cells surface markers in a caspase-dependent and NF-kappa B-independent manner
Plasma processes and polymers, v 13(12), pp 1144-1150
01 Dec 2016
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Exposure to cold physical plasma has been proposed to be of therapeutical value in in oncology via the generation of a number of biologically relevant redox-active molecules. Cancer cells can be recognized and eliminated by cells of the immune system, and accordingly many tumors are populated with these cells, among them T helper cells (TH cells). These lymphocyte population is crucial for effector immune responses against tumor antigens, in response to immunogenic cell death in malignant cells. However, a number of TH populations exists, each having distinct phenotypical features. Using a cold atmospheric pressure argon plasma jet, its redox activity was tested in different TH cell subpopulations to better understand the immunological consequences of potential antitumor plasma treatments in vivo.
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Details
- Title
- Cold physical plasma selects for specific T helper cell subsets with distinct cells surface markers in a caspase-dependent and NF-kappa B-independent manner
- Creators
- Sander Bekeschus - Leibniz Institute for Plasma Science and TechnologyKatrin Roedder - Leibniz Inst Plasma Sci & Technol INP Greifswald, ZIK Plasmatis, Felix Hausdorff Str 2, D-17489 Greifswald, GermanyAnke Schmidt - Leibniz Institute for Plasma Science and TechnologyMatthias B. Stope - Greifswald University HospitalThomas von Woedtke - Leibniz Institute for Plasma Science and TechnologyVandana Miller - 200 Federal Street Suite 500 AJ Drexel Plasma Institute Camden New JerseyAlexander Fridman - Plasma (Russia)Klaus-Dieter Weltmann - Leibniz Institute for Plasma Science and TechnologyKai Masur - Leibniz Institute for Plasma Science and TechnologyHans-Robert Metelmann - Greifswald University HospitalKristian Wende - Leibniz Institute for Plasma Science and TechnologySybille Hasse - Leibniz Institute for Plasma Science and Technology
- Publication Details
- Plasma processes and polymers, v 13(12), pp 1144-1150
- Publisher
- Wiley
- Number of pages
- 7
- Grant note
- 03Z22DN11; 13N13960 / German Federal Ministry of Education and Research; Federal Ministry of Education & Research (BMBF) AU 15 001 / Ministry of Education, Science and Culture of the State of Mecklenburg-Western Pomerania
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology; Mechanical Engineering and Mechanics
- Web of Science ID
- WOS:000393131600002
- Scopus ID
- 2-s2.0-85000347805
- Other Identifier
- 991019168056204721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Physics, Applied
- Physics, Condensed Matter
- Physics, Fluids & Plasmas
- Polymer Science