Journal article
Collagen V-heterozygous and -null supraspinatus tendons exhibit altered dynamic mechanical behaviour at multiple hierarchical scales
Interface focus, v 6(1), 20150043
06 Feb 2016
PMID: 26855746
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Tendons function using a unique set of mechanical properties governed by the extracellular matrix and its ability to respond to varied multi-axial loads. Reduction of collagen V expression, such as in classic Ehlers-Danlos syndrome, results in altered fibril morphology and altered macroscale mechanical function in both clinical and animal studies, yet the mechanism by which changes at the fibril level lead to macroscale functional changes has not yet been investigated. This study addresses this by defining the multiscale mechanical response of wild-type, collagen V-heterozygous and -null supraspinatus tendons. Tendons were subjected to mechanical testing and analysed for macroscale properties, as well as microscale (fibre re-alignment) and nanoscale (fibril deformation and sliding) responses. In many macroscale parameters, results showed a dose-dependent response with severely decreased properties in the null group. In addition, both heterozygous and null groups responded to load faster than in wild-type tendons via earlier fibre realignment and fibril stretch. However, the heterozygous group exhibited increased fibril sliding, while the null group exhibited no fibril sliding. These studies demonstrate that dynamic responses play an important role in determining overall function and that collagen V is a critical regulator in the development of these relationships.
Metrics
Details
- Title
- Collagen V-heterozygous and -null supraspinatus tendons exhibit altered dynamic mechanical behaviour at multiple hierarchical scales
- Creators
- Brianne K. Connizzo - University of PennsylvaniaLin Han - Drexel University, School of Biomedical Engineering, Science, and Health SystemsDavid E. Birk - University of South FloridaLouis J. Soslowsky (Corresponding Author) - University of Pennsylvania
- Publication Details
- Interface focus, v 6(1), 20150043
- Publisher
- The Royal Society
- Number of pages
- 11
- Grant note
- T32-AR007132; AR044745; AR065995 / NIH/NIAMS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS) P30 AR050950 / Penn Center for Musculoskeletal Disorders (NIH); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA P30AR069619 / NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000372065600001
- Scopus ID
- 2-s2.0-84952039886
- Other Identifier
- 991019169587904721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biology