Journal article
Collagen–Hyaluronic Acid Composite Hydrogels with Applications for Chronic Diabetic Wound Repair
ACS biomaterials science & engineering, v 9(9), pp 5376-5388
11 Sep 2023
PMID: 37596956
Abstract
Chronic diabetic wounds have become a major healthcare challenge worldwide. Improper treatment may lead to serious complications. Current treatment methods including biological and physical methods and skin grafting have limitations and disadvantages, such as poor efficacy, inconvenience of use, and high cost. Therefore, developing a more effective and feasible treatment is of great significance for the repair of chronic diabetic wounds. Hydrogels can be designed to serve multiple functions to promote the repair of chronic diabetic wounds. Furthermore, 3D bioprinting enables hydrogel customization to fit chronic diabetic wounds, thus facilitating the healing process. This paper reports a study of 3D printing of a collagen–hyaluronic acid composite hydrogels with application for chronic diabetic wound repair. In situ printed hydrogels were developed by a macromolecular crosslinking network using methacrylated recombinant human collagen (RHCMA) and methacrylated hyaluronic acid (HAMA), both of which can respond to ultraviolet (UV) irradiation. The hydrogels were also loaded with silver nanoclusters (AgNCs) with ultra-small-size nanoparticles, which have the advantages of deep penetration ability and broad-spectrum high-efficiency antibacterial properties. The results of this study show that the developed RHCMA, HAMA, and AgNCs (RHAg) composite hydrogels present good UV responsiveness, porosity, mechanical properties, printability, and biocompatibility, all of which are beneficial to wound healing. The results of this study further show that the developed RHAg hydrogels not only effectively inhibited Staphylococcus aureus and Pseudomonas aeruginosa but also promoted the proliferation and migration of fibroblasts in vitro and tissue regeneration and collagen deposition in vivo, thus producing a desirable wound repair effect and can be used as an effective functional biomaterial to promote chronic diabetic wound repair.
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Details
- Title
- Collagen–Hyaluronic Acid Composite Hydrogels with Applications for Chronic Diabetic Wound Repair
- Creators
- Mujiao Liang - Tsinghua UniversityLina Dong - Tsinghua UniversityZhongwei Guo - School of Mechanics and Safety EngineeringLiming Liu - ShenZhen People’s HospitalZixin Fan - Tsinghua–Berkeley Shenzhen InstituteCunyue Wei - Tsinghua–Berkeley Shenzhen InstituteShengli Mi - Tsinghua UniversityWei Sun - Drexel University, Mechanical Engineering and Mechanics
- Publication Details
- ACS biomaterials science & engineering, v 9(9), pp 5376-5388
- Publisher
- American Chemical Society
- Number of pages
- 13
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Mechanical Engineering and Mechanics
- Web of Science ID
- WOS:001050814100001
- Scopus ID
- 2-s2.0-85170037614
- Other Identifier
- 991021861179904721
InCites Highlights
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Materials Science, Biomaterials