Journal article
Colonic bead expulsion time in normal and μ-opioid receptor deficient (CXBK) mice following central (ICV) administration of μ- and δ-opioid agonists
Life sciences (1973), v 41(19), pp 2229-2234
09 Nov 1987
PMID: 2823042
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Abstract
A method utilizing the insertion of a 3 mm glass bead into the distal colon was used to evaluate the activity of intracerebroventricularly (ICV) administered μ- and δ-opioid agonists on colonic bead expulsion time in mice. Specifically, the ability of two μ-opioid receptor agonists, morphine and [D-Ala
2, NMePhe
4, Gly-ol
5]-enkephalin (DAGO) and a selective δ-opioid receptor agonist, [D-Pen
2, L-Pen
5]-enkephalin (DPLPE), to inhibit colonic bead expulsion time was measured in normal (Swiss) and μ-opioid deficient (CXBK) mice. All three compounds maximally inhibited colonic bead expulsion time in normal mice. All three compounds also inhibited colonic bead expulsion time in CXBK mice, but none maximally. These results are in contrast to previous work in which clear differential analgesic sensitivity of CXBK mice to centrally administered μ- and δ-opioid receptor agonists was observed in the tail-flick test. Taken together, the results suggest (a) that μ-, and possibly δ-, opioid receptors can mediate supraspinal inhibition of colonic bead expulsion in mice and (b) that the genetic deficits of μ-receptor number or genetically-induced alteration in receptor function in CXBK mice do not equally affect inhibition of colonic bead expulsion and tail-flick antinociception.
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Details
- Title
- Colonic bead expulsion time in normal and μ-opioid receptor deficient (CXBK) mice following central (ICV) administration of μ- and δ-opioid agonists
- Creators
- Robert B. Raffa - JanssenJoanne R. MathiasenHenry I. Jacoby
- Publication Details
- Life sciences (1973), v 41(19), pp 2229-2234
- Publisher
- Elsevier; OXFORD
- Number of pages
- 6
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:A1987K343400008
- Scopus ID
- 2-s2.0-0023582964
- Other Identifier
- 991021900195704721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Medicine, Research & Experimental
- Pharmacology & Pharmacy