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Colorectal cancer in inflammatory bowel disease: molecular and clinical features
Journal article   Peer reviewed

Colorectal cancer in inflammatory bowel disease: molecular and clinical features

Sreekant Murthy, Anne Flanigan and Harris Clearfield
Gastroenterology clinics of North America, v 31(2), pp 551-564
Jun 2002
PMID: 12134618

Abstract

Animals Colorectal Neoplasms - etiology Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology Genetic Markers Humans Inflammatory Bowel Diseases - complications Inflammatory Bowel Diseases - genetics Inflammatory Bowel Diseases - pathology Models, Animal Population Surveillance Precancerous Conditions - complications Precancerous Conditions - genetics Precancerous Conditions - pathology Risk Factors United States
The two forms of inflammatory bowel disease (IBD), Crohn's disease and ulcerative colitis, are characterized by chronic and relapsing inflammation of the intestines. Initiating events presumably occur well before patients are symptomatic. Evidence gathered over the past decade from both IBD patients and animal models of intestinal inflammation have confirmed that IBD represents complex heterogenic forms of diseases, influenced by a combination of environmental, genetic, and immunologic factors working in concert to produce exaggerated immune responses, resulting in chronic and remitting inflammation.

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Web of Science research areas
Gastroenterology & Hepatology
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