Files and links (1)
Published, Version of Record (VoR)Open Access (License Unspecified), Open
Journal article
Combination Therapies for Traumatic Brain Injury: Retrospective Considerations
Journal of neurotrauma, v 33(1), pp 11-112
01 Jan 2016
PMID: 25970337
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Patients enrolled in clinical trials for traumatic brain injury (TBI) may present with heterogeneous features over a range of injury severity, such as diffuse axonal injury, ischemia, edema, hemorrhage, oxidative damage, mitochondrial and metabolic dysfunction, excitotoxicity, inflammation, and other pathophysiological processes. To determine whether combination therapies might be more effective than monotherapy at attenuating moderate TBI or promoting recovery, the National Institutes of Health funded six preclinical studies in adult and immature male rats to evaluate promising acute treatments alone and in combination. Each of the studies had a solid rationale for its approach based on previous research, but only one reported significant improvements in long-term outcomes across a battery of behavioral tests. Four studies had equivocal results because of a lack of sensitivity of the outcome assessments. One study demonstrated worse results with the combination in comparison with monotherapies. While specific research findings are reported elsewhere, this article provides an overview of the study designs, insights, and recommendations for future research aimed at therapy development for TBI.
Metrics
Details
- Title
- Combination Therapies for Traumatic Brain Injury: Retrospective Considerations
- Creators
- Susan Margulies - 1Department of Bioengineering, University of Pennsylvania, Philadelphia, PennsylvaniaGail Anderson - 2Department of Pharmacy, Pharmaceutics, and Neurological Surgery, University of Washington, Seattle, WashingtonFahim Atif - 3Department of Emergency Medicine, Emory University, Atlanta, GeorgiaJerome Badaut - 4Institut of Neuroscience Cognitive and Integrative of Aquitaine (INCIA), University of Bordeaux, Bordeaux, FranceRobert Clark - 5Safar Center for Resuscitation Research and Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PennsylvaniaPhilip Empey - 6Department of Pharmacy and Therapeutics, University of Pittsburgh School of Pharmacy, Pittsburgh, PennsylvaniaMaria Guseva - 7Fresenius Kabi USA, LLC, Lake Zurich, IllinoisMichael Hoane - 8Department of Psychology, Southern Illinois University, Carbondale, IllinoisJimmy Huh - 9Department of Anesthesiology and Critical Care, Children's Hospital of Philadelphia, Philadelphia, PennsylvaniaJim Pauly - 10Department of Pharmaceutical Sciences, University of Kentucky, Lexington, KentuckyRamesh Raghupathi - Drexel UniversityStephen Scheff - 12Center on Aging, University of Kentucky, Lexington, KentuckyDonald Stein - 3Department of Emergency Medicine, Emory University, Atlanta, GeorgiaHuiling Tang - 3Department of Emergency Medicine, Emory University, Atlanta, GeorgiaMona Hicks - 13One Mind, Seattle, Washington
- Publication Details
- Journal of neurotrauma, v 33(1), pp 11-112
- Publisher
- Mary Ann Liebert, Inc
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000367057200013
- Scopus ID
- 2-s2.0-84952949019
- Other Identifier
- 991019167783204721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Clinical Neurology
- Critical Care Medicine
- Neurosciences