Journal article
Combination of baicalein and ethanol-wet-bonding improves dentin bonding durability
Journal of dentistry, v 90, 103207
Nov 2019
PMID: 31586587
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
This study aimed to investigate the potential of baicalein combined with ethanol-wet bonding (EWB) in improving dentin bonding durability.
Sixty caries-free human third molars were randomly allocated into four groups and pretreated with solutions after sectioning and polishing. The pretreatments were prepared via dissolving baicalein in ethanol at concentrations of 0, 0.01%, 0.05% and 0.1% (w/v). Microtensile bond strength (MTBS) test, failure mode analysis and interfacial nanoleakage evaluation were conducted immediately or after thermocycling or 1 month of collagenase aging. In situ zymography, contact angle, antibacterial activity and bioactivity were comprehensively assessed.
Results demonstrated that the three experimental groups exhibited higher MTBS and lower nanoleakage expression regardless of aging. MMP activity within hybrid layer and Streptococcus. mutans biofilm formation were inhibited in the experimental groups in a dose-dependent manner. Baicalein also reduced reactive oxygen species (ROS) expression in human dental pulp cells and resisted adhesive-induced cytotoxicity. Baicalein exhibited remarkable capabilities at concentrations higher than 0.05% (w/v).
Baicalein is a prospective candidate as bioactive dentin bonding agent. Combined with EWB, baicalein may form a functional bonding interface, thereby enhancing dentin bond strength and durability.
Joint efforts by baicalein and EWB provides a novel therapeutic strategy for obtaining ideal adhesive-dentin interface and prolonging the longevity of restorations.
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Details
- Title
- Combination of baicalein and ethanol-wet-bonding improves dentin bonding durability
- Creators
- Luyao Yi - Wuhan UniversityJian Yu - Wuhan UniversityLin Han - CR&WISCO General Hospital, Wuhan, China.Tingting Li - Lanzhou Hospital of Stomatology, Lanzhou, China.Hongye Yang - Wuhan UniversityCui Huang - Wuhan University
- Publication Details
- Journal of dentistry, v 90, 103207
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000496190900004
- Scopus ID
- 2-s2.0-85074410963
- Other Identifier
- 991019187054804721
UN Sustainable Development Goals (SDGs)
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Dentistry, Oral Surgery & Medicine