Journal article
Combined Vitamin D and Magnesium Supplementation Does Not Influence Markers of Bone Turnover or Glycemic Control: A Randomized Controlled Clinical Trial
Nutrition research (New York, N.Y.)
Dec 2022
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
High dose vitamin D supplementation can increase total osteocalcin concentrations that may reduce insulin resistance in individuals at risk for prediabetes or diabetes mellitus. Magnesium is a cofactor in vitamin D metabolism and activation. The purpose of this study was to determine the combined effect of vitamin D and magnesium supplementation on total osteocalcin concentrations, glycemic indices, and other bone turnover markers after a 12-week intervention in individuals who were overweight and obese, but otherwise healthy. We hypothesized that combined supplementation would improve serum total osteocalcin concentrations and glycemic indices more than vitamin D supplementation alone, or a placebo. A total of 78 women and men completed this intervention in three groups: a vitamin D and magnesium group (1000 IU vitamin D3 and 360 mg magnesium glycinate), a vitamin D group (1000 IU vitamin D3) and a placebo group. Despite a significant increase in serum 25-hydroxyvitamin D concentrations in the vitamin D and magnesium group compared to the placebo group (Difference=5.63, CI=-10.0 to -1.21, p=0.001) post-intervention, there were no differences in serum concentrations of total osteocalcin, glucose, insulin, adiponectin, and the homeostatic model assessment of insulin resistance (HOMA-IR) among groups (p>0.05 for all). Additionally, total osteocalcin (β=-0.310, p=0.081), bone-specific alkaline phosphatase (β=0.004, p=0.986), and C-terminal cross-linked telopeptide (β=0.426, p=0.057), were not significant predictors of HOMA-IR after the intervention. Combined supplementation was not associated with short-term improvements in glycemic indices or bone turnover markers in participants who were overweight and obese in our study. This trial was registered at clinicaltrials.gov (NCT03134417).
In a 12-week intervention of individuals who were overweight and obese, despite increasing serum 25-hydroxyvitamin D concentrations, combined vitamin D and magnesium supplementation did not improve serum concentrations of total osteocalcin, glucose, insulin, HOMA-IR, or adiponectin. Total osteocalcin, BAP, and CTX were not predictors of HOMA-IR after the intervention. BAP, bone-specific alkaline phosphatase; CTX, carboxy-terminal collagen crosslinks; HOMA-IR, homeostatic model assessment of insulin resistance; IU, international unit; 25(OH)D, 25-hydroxyvitamin D. [Display omitted]
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Details
- Title
- Combined Vitamin D and Magnesium Supplementation Does Not Influence Markers of Bone Turnover or Glycemic Control: A Randomized Controlled Clinical Trial
- Creators
- Rosemary D Dall - Drexel University Department of Nutrition SciencesMay M Cheung - Monell Chemical Senses CenterPatricia A Shewokis - Drexel University Department of Nutrition SciencesAsma Altasan - Drexel University Department of Nutrition SciencesStella L Volpe - Virginia TechRenee Amori - St. Luke's University Health NetworkHarpreet Singh - The Ohio State College of MedicineDeeptha Sukumar - Drexel University Department of Nutrition Sciences
- Publication Details
- Nutrition research (New York, N.Y.)
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Nutrition Sciences
- Web of Science ID
- WOS:000925254700001
- Scopus ID
- 2-s2.0-85147111343
- Other Identifier
- 991019518902604721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Nutrition & Dietetics