Journal article
Combined effects of methamphetamine and zolpidem on performance and mood during simulated night shift work
Pharmacology, biochemistry and behavior, v 81(3), pp 559-568
2005
PMID: 15936062
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Individuals who work irregular or rotating shifts often use stimulants and sedatives to offset shift-change-related mood and performance decrements. During this simulated shift work study the acute effects of the stimulant, methamphetamine were examined, and the effects of the hypnotic, zolpidem, and the combination were assessed during the shift after drug administration. Eight volunteers completed this 21-day, within-participant, residential laboratory study during which they received a single oral methamphetamine dose (0 or 10 mg) 1 h after waking, i.e., before task performance, and a single oral zolpidem dose (0 or 10 mg) 1 h before bedtime under 2 shift conditions: day shift and night shift. When participants received placebo at both dosing times, performance on some psychomotor tasks (e.g., the digit-symbol substitution task) and on some measures of mood (e.g., ratings of “Energetic”) were disrupted during the night shift, relative to the day shift. Methamphetamine alone eliminated virtually all shift-related disruptions, while zolpidem alone and the drug combination produced few effects. These data indicate that shift changes produce performance impairments and mood alterations that are improved by a single low to moderate dose of methamphetamine. Zolpidem, given alone or in combination with methamphetamine, did not alleviate most shift-change mood and performance effects.
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Details
- Title
- Combined effects of methamphetamine and zolpidem on performance and mood during simulated night shift work
- Creators
- Carl L Hart - New York State Psychiatric InstituteMargaret Haney - New York State Psychiatric InstituteJennifer Nasser - New York State Psychiatric InstituteRichard W Foltin - New York State Psychiatric Institute
- Publication Details
- Pharmacology, biochemistry and behavior, v 81(3), pp 559-568
- Publisher
- Elsevier
- Number of pages
- 10
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Nutrition Sciences; Health Sciences
- Web of Science ID
- WOS:000230970400018
- Scopus ID
- 2-s2.0-22044443131
- Other Identifier
- 991014878062804721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Behavioral Sciences
- Neurosciences
- Pharmacology & Pharmacy