Journal article
Combined histomorphometric and gene-expression profiling applied to toxicology
GenomeBiology.com, v 4(5), R32
30 Apr 2003
PMID: 12734012
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
A unique methodology has been developed for the combined analysis of histomorphometric and gene-expression profiles amenable to intensive data mining and multisample comparison for a comprehensive approach to toxicology.
We have developed a unique methodology for the combined analysis of histomorphometric and gene-expression profiles amenable to intensive data mining and multisample comparison for a comprehensive approach to toxicology. This hybrid technology, termed extensible morphometric relational gene-expression analysis (EMeRGE), is applied in a toxicological study of time-varied vehicle- and carbon-tetrachloride (CCl
4
)-treated rats, and demonstrates correlations between specific genes and tissue structures that can augment interpretation of biological observations and diagnosis.
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Details
- Title
- Combined histomorphometric and gene-expression profiling applied to toxicology
- Creators
- Andres Kriete (Corresponding Author) - TissueInformatics Inc (United States, Pittsburgh)Mary K Anderson - InforMax (United States, Frederick)Brad Love - InforMax (United States, Frederick)John Freund - TissueInformatics Inc (United States, Pittsburgh)James J Caffrey - InforMax (United States, Frederick)M Brook Young - Motorola Life Sciences (United States, Northbrook)Timothy J Sendera - Motorola Life Sciences (United States, Northbrook)Scott R Magnuson - Motorola Life Sciences (United States, Northbrook)J Mark Braughler - TissueInformatics Inc (United States, Pittsburgh)
- Publication Details
- GenomeBiology.com, v 4(5), R32
- Publisher
- BioMed Central; London
- Number of pages
- 9
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000182698600008
- Scopus ID
- 2-s2.0-0038681577
- Other Identifier
- 991014878389904721
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- Web of Science research areas
- Biotechnology & Applied Microbiology
- Genetics & Heredity