Journal article
Combining Therapeutic Strategies to Treat the Injured Spinal Cord: A Translational Perspective
Journal of neurotrauma, v 42(23-24), pp 2129-2148
01 Dec 2025
PMID: 40929022
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Spinal cord injury (SCI) results in an array of debilitating, sometimes permanent-and at times life-threatening-motor, sensory, and autonomic deficits. A broad range of therapies have been tested pre-clinically, and there has been a significant acceleration in recent years of clinical translation of potential treatments. However, it is widely appreciated among scientists and clinical professionals alike that there likely is no "silver bullet" (single treatment) that will result in complete functional restoration after SCI. The combination of more than one treatment approach, especially treatments that can have distinct beneficial effects, increases the probability of functional improvement. This review highlights the mounting interest in the pre-clinical development and application of combination strategies to treat SCI, and some of the translational efforts made to combine promising therapies for clinical evaluation. Special attention is given to barriers and limitations faced in translating treatments for people living with SCI.
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Details
- Title
- Combining Therapeutic Strategies to Treat the Injured Spinal Cord: A Translational Perspective
- Creators
- Benjamin C Sherman - Drexel UniversityMary Schmidt Read - Thomas Jefferson University HospitalDaniel J Hoh - University of FloridaJames D Guest - University of MiamiMichael A Lane - Drexel University, Neurobiology and AnatomyLyandysha V Zholudeva - Drexel University, Neurobiology and Anatomy
- Publication Details
- Journal of neurotrauma, v 42(23-24), pp 2129-2148
- Publisher
- Journal of neurotrauma
- Number of pages
- 19
- Grant note
- R01 NS104291 / NINDS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:001570479400001
- Scopus ID
- 2-s2.0-105015793259
- Other Identifier
- 991022097406104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Clinical Neurology
- Critical Care Medicine
- Neurosciences