Journal article
Common Genetic Variation, Residential Proximity to Traffic Exposure, and Left Ventricular Mass: The Multi-Ethnic Study of Atherosclerosis
Environmental health perspectives, v 118(7), pp 962-969
01 Jul 2010
PMID: 20308035
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
BACKGROUND: Elevated left ventricular mass (LVM) is a strong predictor of negative cardiovascular outcomes, including heart failure, stroke, and sudden cardiac death. A relationship between close (< 50 m compared with > 150 m) residential proximity to major roadways and higher LVM has previously been described, but the mechanistic pathways that are involved in this relationship are not known. Understanding genetic factors that influence susceptibility to these effects may provide insight into relevant mechanistic pathways.
OBJECTIVE: We set out to determine whether genetic polymorphisms in genes affecting vascular and autonomic function, blood pressure, or inflammation influence the relationship between traffic proximity and LVM.
METHODS: This was a cross-sectional study of 1,376 genotyped participants in the Multi-Ethnic Study of Atherosclerosis, with cardiac magnetic resonance imaging performed between 2000 and 2002. The impact of tagged single-nucleotide polymorphisms (tagSNPs) and inferred haplotypes in 12 candidate genes (ACE, ADRB2, AGT, AGTR1, ALOX15, EDN1, GRK4, PTGS1, PTGS2, TLR4, VEGFA, and VEGFB) on the relationship between residential proximity to major roadways and LVM was analyzed using multiple linear regression, adjusting for multiple potential confounders.
RESULTS: After accounting for multiple testing and comparing homozygotes, tagSNPs in the type 1 angiotensin II receptor (AGTR1, rs6801836) and arachidonate 15-lipoxygenase (ALOX15, rs2664593) genes were each significantly (q < 0.2) associated with a 9-10% difference in the association between residential proximity to major roadways and LVM. Participants with suboptimal blood pressure control demonstrated stronger interactions between AGTR1 and traffic proximity.
CONCLUSIONS: Common polymorphisms in genes responsible for vascular function, inflammation, and oxidative stress appear to modify associations between proximity to major roadways and LVM. Further understanding of how genes modify effects of air pollution on CVD may help guide research efforts into specific mechanistic pathways.
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Details
- Title
- Common Genetic Variation, Residential Proximity to Traffic Exposure, and Left Ventricular Mass: The Multi-Ethnic Study of Atherosclerosis
- Creators
- Victor C. Van Hee - University of WashingtonSara D. Adar - University of WashingtonAdam A. Szpiro - University of WashingtonR. Graham Barr - Columbia UniversityAna Diez Roux - University of MichiganDavid A. Bluemke - National Institutes of HealthLianne Sheppard - University of WashingtonEdward A. Gill - University of WashingtonHossein Bahrami - Johns Hopkins UniversityChristina Wassel - University of MinnesotaMichele M. Sale - Cedars-Sinai Medical CenterDavid S. Siscovick - University of WashingtonJerome I. Rotter - Cedars-Sinai Medical CenterStephen S. Rich - University of VirginiaJoel D. Kaufman - University of Washington
- Publication Details
- Environmental health perspectives, v 118(7), pp 962-969
- Publisher
- Us Dept Health Human Sciences Public Health Science
- Number of pages
- 8
- Grant note
- P50ES015915; P30ES07033; K24ES013195 / National Institute of Environmental Health Sciences; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) K24ES013195 / NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) R01HL071205 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) N01HC095161 / DIVISION OF EPIDEMIOLOGY AND CLINICAL APPLICATIONS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Eye Institute (NEI) ZIACL090019 / CLINICAL CENTER N01-HC-95159; N01-HC-95165; N01-HC-95169; R01 HL077612; HL070151; HL071205; HL071251-52; HL071258-59; T32HL07902 / National Heart, Lung, and Blood Institute; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) RD831697 / U.S. Environmental Protection Agency; United States Environmental Protection Agency ZIAEB000072 / NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Biomedical Imaging & Bioengineering (NIBIB)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative; Epidemiology and Biostatistics
- Web of Science ID
- WOS:000279435400025
- Scopus ID
- 2-s2.0-77954835219
- Other Identifier
- 991020112305704721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Environmental Sciences
- Public, Environmental & Occupational Health
- Toxicology