Journal article
Common patterns of bcl-2 family gene expression in two traumatic brain injury models
Neurotoxicity research, v 6(4), pp 333-342
2004
PMID: 15545017
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Cell death/survival following traumatic brain injury (TBI) may be a result of alterations in the intracellular ratio of death and survival factors. Bcl-2 family genes mediate both cell survival and the initiation of cell death. Using lysate RNase protection assays, mRNA expression of the anti-cell death genes Bcl-2 and Bcl-xL, and the pro-cell death gene Bax, was evaluated following experimental brain injuries in adult male Sprague-Dawley rats. Both the lateral fluid-percussion (LFP) and the lateral controlled cortical impact (LCI) models of TBI showed similar patterns of gene expression. Anti-cell death bcl-2 and bcl-xL mRNAs were attenuated early and tended to remain depressed for at least 3 days after injury in the cortex and hippocampus ipsilateral to injury. Pro-cell death bax mRNA was elevated in these areas, usually following the decrease in anti-cell death genes. These common patterns of gene expression suggest an important role for Bcl-2 genes in cell death and survival in the injured brain. Understanding the regulation of these genes may facilitate the development of new therapeutic strategies for a condition that currently has no proven pharmacologic treatments.
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Details
- Title
- Common patterns of bcl-2 family gene expression in two traumatic brain injury models
- Creators
- Kenneth I Strauss - Department of Neurosurgery, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA. kstrauss@uc.eduRaj K NarayanRamesh Raghupathi
- Publication Details
- Neurotoxicity research, v 6(4), pp 333-342
- Publisher
- Springer Nature; United States
- Grant note
- R01 NS038654 / NINDS NIH HHS R01 NS038654-03 / NINDS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000225798600012
- Scopus ID
- 2-s2.0-21644490153
- Other Identifier
- 991014877882404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences