Journal article
Comparative analysis of oxygenator dysfunction in polymethylpentene oxygenators: A pilot study
Perfusion, v 40(4)
01 Aug 2024
PMID: 39089248
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Introduction: Polymethylpentene (PMP) oxygenators serve as the primary oxygenator type utilized for ECMO. With the number of PMP oxygenators available, it has become increasingly important to determine differences among each oxygenator type that can lead to varying metrics of oxygenator dysfunction. Methods: This study was a retrospective, single-center analysis of adult patients supported on ECMO between December 2020 to December 2021 with varying PMP oxygenators including the Medtronic Nautilus Smart (Minneapolis, MA), the Eurosets AMG PMP (Medolla, Italy) and Getinge Quadrox-iD and the Getinge Cardiohelp HLS Module Advanced System (Gothenberg, Sweden). Results: A total of 19 patients were included in our study. 10 patients (52.6%) were supported with a Medtronic Nautilus Smart oxygenator, 5 patients (26.3%) were supported with an Eurosets AMG PMP Oxygenator, and 4 patients (21.1%) were supported with either a Getinge Quadrox-iD oxygenator or Getinge Cardiohelp HLS system. Patients supported with Eurosets AMG PMP oxygenators experienced higher resistance and lower post-oxygenator PaO2 in comparison to other cohorts (p < .02 and < .002 respectively). There was no difference in measured oxygen transfer between cohorts (p = .667). Two patients, both supported by Eurosets AMG PMP, experienced oxygenator failure (p = .094). Conclusion: Radial flow oxygenators are prone to higher resistance and lower post-oxygenator PaO2when compared to transverse flow oxygenators. Future larger multicenter studies are required to fully discern the differences between flow-varying polymethylpentene oxygenators and their appropriate cutoffs for oxygenator dysfunction.
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Details
- Title
- Comparative analysis of oxygenator dysfunction in polymethylpentene oxygenators: A pilot study
- Creators
- Shan P. Modi - Allegheny Health NetworkBrandon D'Aloiso - University of PittsburghAmber Palmer - University of Pittsburgh Medical CenterStephanie Smith - University of Pittsburgh Medical CenterPeter Arlia - University of Pittsburgh Medical CenterMichael Anselmi - West Virginia UniversityPablo Sanchez - University of PittsburghRaj Ramanan (Corresponding Author) - University of Pittsburgh
- Publication Details
- Perfusion, v 40(4)
- Publisher
- Sage
- Number of pages
- 8
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Surgery; Emergency Medicine; Environmental and Occupational Health
- Web of Science ID
- WOS:001283035700001
- Scopus ID
- 2-s2.0-85200260250
- Other Identifier
- 991022008087204721
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InCites Highlights
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Cardiac & Cardiovascular Systems
- Peripheral Vascular Disease