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Journal article
Comparative assessment of radiation therapy-induced vasculitis using [ 18 F]FDG-PET/CT in patients with non-small cell lung cancer treated with proton versus photon radiotherapy
European journal of nuclear medicine and molecular imaging, v 51(5), pp 1444-1450
Apr 2024
PMID: 38095673
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
To assess radiation therapy (RT)-induced vasculitis in patients with non-small cell lung cancer (NSCLC) by examining changes in the uptake of F-fluoro-D-deoxyglucose ([ F]FDG) by positron emission tomography/computed tomography (PET/CT) images of the ascending aorta (AA), descending aorta (DA), and aortic arch (AoA) before and after proton and photon RT.
Thirty-five consecutive locally advanced NSCLC patients were definitively treated with proton (n = 27) or photon (n = 8) RT and concurrent chemotherapy. The patients were prospectively enrolled to undergo [F]FDG-PET/CT imaging before and 3 months after RT. An adaptive contrast-oriented thresholding algorithm was applied to generate mean standardized uptake values (SUVmean) for regions of interest (ROIs) 3 mm outside and 3 mm inside the outer perimeter of the AA, DA, and AoA. These ROIs were employed to exclusively select the aortic wall and remove the influence of blood pool activity. SUVmeans before and after RT were compared using two-tailed paired t-tests.
RT treatments were associated with increased SUVmeans in the AA, DA, and AoA-1.9%, 0.3%, and 1.3% for proton and 15.8%, 9.5%, and 15.5% for photon, respectively. There was a statistically significant difference in the ∆SUVmean (post-RT SUVmean - pre-RT SUVmean) in patients treated with photon RT when compared to ∆SUVmean in patients treated with proton RT in the AA (p = 0.043) and AoA (p = 0.015). There was an average increase in SUVmean that was related to dose for photon patients (across structures), but that was not seen for proton patients, although the increase was not statistically significant.
Our results suggest that patients treated with photon RT for NSCLC may exhibit significantly more RT-induced inflammation (measured as ∆SUVmean) in the AA and AoA when compared to patients who received proton RT. Knowledge gained from further analyses in larger cohorts could aid in treatment planning and help prevent the significant morbidity and mortality associated with RT-induced vascular complications.
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Details
- Title
- Comparative assessment of radiation therapy-induced vasculitis using [ 18 F]FDG-PET/CT in patients with non-small cell lung cancer treated with proton versus photon radiotherapy
- Creators
- D Evanson - Drexel UniversityM Griffin - Drexel UniversityS E O'Reilly - University of PennsylvaniaT Johnson - University of Notre DameT Werner - Hospital of the University of PennsylvaniaE Kothekar - University of PennsylvaniaP Jahangiri - University of PennsylvaniaC B Simone, 2nd - New York Proton CenterS Swisher-McClure - University of PennsylvaniaS J Feigenberg - University of PennsylvaniaM-E Revheim - Oslo University HospitalJ Zou - University of PennsylvaniaA Alavi - Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, USA
- Publication Details
- European journal of nuclear medicine and molecular imaging, v 51(5), pp 1444-1450
- Publisher
- Springer Nature
- Number of pages
- 7
- Grant note
- R25 CA140116 / NCI NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine
- Web of Science ID
- WOS:001125141400006
- Scopus ID
- 2-s2.0-85179730604
- Other Identifier
- 991021861275704721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Radiology, Nuclear Medicine & Medical Imaging