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Journal article
Comparative genome-wide association studies of a depressive symptom phenotype in a repeated measures setting by race/ethnicity in the multi-ethnic study of atherosclerosis
BMC genetics, v 16(1), pp 118-118
12 Oct 2015
PMID: 26459564
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background: Time-varying phenotypes have been studied less frequently in the context of genome-wide analyses across ethnicities, particularly for mood disorders. This study uses genome-wide association studies of depressive symptoms in a longitudinal framework and across multiple ethnicities to find common variants for depressive symptoms. Ethnicity-specific GWAS for depressive symptoms were conducted using three approaches: a baseline measure, longitudinal measures averaged over time, and a repeated measures analysis. We then used meta-analysis to jointly analyze the results across ethnicities within the Multi-ethnic Study of Atherosclerosis (MESA, n = 6,335), and then within ethnicity, across MESA and a sample from the Health and Retirement Study African-and European-Americans (HRS, n = 10,163).
Methods: This study uses genome-wide association studies of depressive symptoms in a longitudinal framework and across multiple ethnicities to find common variants for depressive symptoms. Ethnicity-specific GWAS for depressive symptoms were conducted using three approaches: a baseline measure, longitudinal measures averaged over time, and a repeated measures analysis. We then used meta-analysis to jointly analyze the results across ethnicities within the Multi-ethnic Study of Atherosclerosis (MESA, n = 6,335), and then within ethnicity, across MESA and a sample from the Health and Retirement Study African-and European-Americans (HRS, n = 10,163).
Results: Several novel variants were identified at the genome-wide suggestive level (5x10(-8) < p-value = 5x10(-6)) in each ethnicity for each approach to analyzing depressive symptoms. The repeated measures analyses resulted in typically smaller p-values and an increase in the number of single-nucleotide polymorphisms (SNP) reaching genome-wide suggestive level.
Conclusions: For phenotypes that vary over time, the detection of genetic predictors may be enhanced by repeated measures analyses.
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Details
- Title
- Comparative genome-wide association studies of a depressive symptom phenotype in a repeated measures setting by race/ethnicity in the multi-ethnic study of atherosclerosis
- Creators
- Erin B. Ware - University of Michigan–Ann ArborBhramar Mukherjee - University of Michigan–Ann ArborYan V. Sun - Emory UniversityAna V. Diez-Roux - Drexel UniversitySharon L. R. Kardia - University of Michigan–Ann ArborJennifer A. Smith - University of Michigan–Ann Arbor
- Publication Details
- BMC genetics, v 16(1), pp 118-118
- Publisher
- Springer Nature
- Number of pages
- 11
- Grant note
- National Heart, Lung, and Blood Institute (NHLBI); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) N01-HC-95159; N01-HC-95169; UL1-RR-024156 / MESA N01HC095163 / DIVISION OF EPIDEMIOLOGY AND CLINICAL APPLICATIONS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Eye Institute (NEI) R01HL065226 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) NIA U01AG009740; RC2 AG036495; RC4 AG039029 / National Institute on Aging; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) NIH Center for Inherited Disease Research (CIDR) at Johns Hopkins University UL1RR024156 / NATIONAL CENTER FOR RESEARCH RESOURCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) N02-HL-6-4278; N01-HC-65226 / NHLBI; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) P60MD002249 / National Institute on Minority Health and Health Disparities; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Minority Health & Health Disparities (NIMHD) U01AG009740 / NATIONAL INSTITUTE ON AGING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative
- Web of Science ID
- WOS:000362537500001
- Scopus ID
- 2-s2.0-84944056972
- Other Identifier
- 991019169597904721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Genetics & Heredity