Journal article
Comparative mapping of rat Iddm4 to segments on HSA7 and MMU6
Mammalian genome, v 15(1)
Jan 2004
PMID: 14727142
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Iddm4 is one of several susceptibility genes that have been identified in the BB rat model of type 1 diabetes. The BB rat allele of this gene confers dominant predisposition to diabetes induction by immune perturbation in both the diabetes-prone and the diabetes-resistant substrains, whereas the Wistar Furth (WF) allele confers resistance. We have positioned the gene in a 2.8-cM region on rat Chromosome (Chr) 4, proximal to Lyp/Ian4l1. We have produced a radiation hybrid map of the Iddm4-region that includes a number of rat genes with their mouse and human orthologs. We present a comparative map of the rat Iddm4 region in rat, human, and mouse, assigning the gene to a 6.3-Mb segment between PTN and ZYX at 7q32 in the human genome, and to a 5.7-Mb segment between Ptn and Zyx in the mouse genome.
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Details
- Title
- Comparative mapping of rat Iddm4 to segments on HSA7 and MMU6
- Creators
- Lars Hornum - Hagedorn Research Institute, Niels Steensens Vej 6, DK-2820 Gentofte DenmarkCheryl DeScipio - Department of Microbiology and Immunology Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, Pennsylvania 19129 USAHelle Markholst - Hagedorn Research Institute, Niels Steensens Vej 6, DK-2820 Gentofte DenmarkScott Troutman - Department of Microbiology and Immunology Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, Pennsylvania 19129 USAStephen Novak - Department of Microbiology and Immunology Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, Pennsylvania 19129 USAJean Leif - Diabetes Division University of Massachusetts Medical School, 373 Plantation Street, #218, Worcester, Massachusetts USADale Greiner - Diabetes Division University of Massachusetts Medical School, 373 Plantation Street, #218, Worcester, Massachusetts USAJohn Mordes - Diabetes Division University of Massachusetts Medical School, 373 Plantation Street, #218, Worcester, Massachusetts USAElizabeth Blankenhorn - Department of Microbiology and Immunology Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, Pennsylvania 19129 USA
- Publication Details
- Mammalian genome, v 15(1)
- Publisher
- Springer-Verlag; New York
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- [Retired Faculty]
- Web of Science ID
- WOS:000187926100006
- Scopus ID
- 2-s2.0-0346040471
- Other Identifier
- 991014877806404721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Biotechnology & Applied Microbiology
- Genetics & Heredity