Journal article
Comparative mechanics of diverse mammalian carotid arteries
PloS one, v 13(8), e0202123
10 Aug 2018
PMID: 30096185
Abstract
The prevalence of diverse animal models as surrogates for human vascular pathologies necessitate a comprehensive understanding of the differences that exist between species. Comparative passive mechanics are presented here for the common carotid arteries taken from bovine, porcine, ovine, leporine, murine-rat, and murine-mouse specimens. Data is generated using a scalable biaxial mechanical testing device following consistent circumferential (pressure-diameter) and axial (force-length) testing protocols. The structural mechanical response of carotids under equivalent loading, quantified by the deformed inner radius, deformed wall thickness, lumen area compliance and axial force, varies significantly among species but generally follows allometric scaling. Conversely, descriptors of the local mechanical response within the deformed arterial wall, including mean circumferential stress, mid-wall circumferential stretch, and mean axial stress, are relatively consistent across species. Unlike the larger animals studied, the diameter distensibility curves of murine specimens are non-monotonic and have a significantly higher value at 100 mmHg. Taken together, our results provide baseline structural and mechanical information for carotid arteries across a broad range of common animal models.
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Details
- Title
- Comparative mechanics of diverse mammalian carotid arteries
- Creators
- David A Prim - University of South CarolinaMohamed A Mohamed - University of HoustonBrooks A Lane - University of South CarolinaKelley Poblete - Texas Woman's UniversityMark A Wierzbicki - Texas A&M UniversitySusan M Lessner - University of South CarolinaTarek Shazly - University of South CarolinaJohn F Eberth - University of South Carolina
- Publication Details
- PloS one, v 13(8), e0202123
- Publisher
- Public LIbrary of Science (PLOS)
- Grant note
- R01 HL133662 / NHLBI NIH HHS R21 EB022131 / NIBIB NIH HHS P20 GM103499 / NIGMS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000441308500051
- Scopus ID
- 2-s2.0-85051643576
- Other Identifier
- 991021902595504721
InCites Highlights
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Engineering, Biomedical