Logo image
Back
Comparative risk of postoperative complications after total shoulder arthroplasty in patients with non-alcoholic cirrhosis versus NAFLD: A matched national cohort study
Journal article   Open access   Peer reviewed

Comparative risk of postoperative complications after total shoulder arthroplasty in patients with non-alcoholic cirrhosis versus NAFLD: A matched national cohort study

Catherine Hand, Jared Sasaki, Camden Bohn, Matthew Varano, Daniel Shinn, Matthew Henriques, Nicholas Lemme and Brian Forsythe
Shoulder & elbow, Forthcoming
12 Jan 2026
DOI: https://doi.org/10.1177/17585732251412432
PMID: 41536540
url
https://pmc.ncbi.nlm.nih.gov/articles/PMC12795727/View
Open

Abstract

Life Sciences & Biomedicine Science & Technology Orthopedics
Background This retrospective database study evaluates postoperative complications following total shoulder arthroplasty (TSA) in patients with non-alcoholic cirrhosis (NAC) versus non-alcoholic fatty liver disease (NAFLD) using a large matched national cohort.Materials and Methods Among 266,263 patients who underwent TSA, 171,059 had continuous enrollment and were undergoing TSA for the first time. Out of this group, 1986 patients had NAC and 4240 had NAFLD. Propensity-score matching was conducted controlling for age, sex, Charlson Comorbidity Index, and key clinical covariates, resulting in a final cohort of 2170 total patients (1085 per group). Multivariable logistic regression was used to compare 90-day and one-year postoperative complication rates.Results Within 90 days postoperatively, patients with NAC had higher rates of acute kidney injury, blood transfusion, and any complication compared to patients with NAFLD. At one year, NAC patients continued to show higher odds of blood transfusion and overall complications, while NAFLD patients had significantly higher deep vein thrombosis incidence.Discussion Patients with NAC undergoing TSA are at increased risk for postoperative complications compared to those with NAFLD. Although NAFLD patients had fewer adverse outcomes, they exhibited elevated thromboembolic risk at one year. Tailored perioperative strategies to liver disease subtype patients are needed to help mitigate postoperative complications in this vulnerable population.

Metrics

1 Record Views

Details

UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

Source: SDGs in the Output

InCites Highlights

Data related to this publication, from InCites Benchmarking & Analytics tool:

Collaboration types
Domestic collaboration
Web of Science research areas
Orthopedics
Logo image