Journal article
Comparative semantic profiles in semantic dementia and Alzheimer's disease
Brain (London, England : 1878), v 136(Pt 8), pp 2497-2509
01 Aug 2013
PMID: 23824492
Abstract
Patients with the semantic variant of primary progressive aphasia, also known as semantic dementia, and Alzheimer's disease have deficits in semantic memory. However, few comparative studies have been performed to determine whether these patient groups have distinct semantic memory impairments. We asked 15 patients with semantic variant primary progressive aphasia and 57 patients with Alzheimer's disease to judge semantic category membership of coloured photos and printed words that are members of familiar natural and manufactured categories, and we related performance to grey matter atrophy. We found that both semantic variant primary progressive aphasia and Alzheimer's disease are significantly impaired on this task. Moreover, patients with semantic variant primary progressive aphasia had a significantly more prominent deficit for natural objects than their own deficit judging manufactured objects. Both semantic variant primary progressive aphasia and Alzheimer's disease had atrophy that included portions of the left temporal lobe. Regression analyses related performance in semantic variant primary progressive aphasia to ventral and medial portions of the left temporal lobe, while regression analyses in Alzheimer's disease related performance to these ventral and medial temporal areas as well as lateral temporal-parietal regions in the left hemisphere. We conclude that both semantic variant primary progressive aphasia and Alzheimer's disease are significantly impaired in a simple category membership judgement task and the selective impairment for natural kinds in semantic variant primary progressive aphasia is related in part to disease in visual association cortex in ventral-medial portions of the left temporal lobe. We discuss factors that may contribute to the semantic memory deficit in semantic variant primary progressive aphasia.
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Details
- Title
- Comparative semantic profiles in semantic dementia and Alzheimer's disease
- Creators
- David J Libon - Drexel UniversityKatya Rascovsky - Hospital of the University of PennsylvaniaJohn Powers - Hospital of the University of PennsylvaniaDavid J Irwin - Hospital of the University of PennsylvaniaAshley Boller - Hospital of the University of PennsylvaniaDanielle Weinberg - Hospital of the University of PennsylvaniaCorey T McMillan - Hospital of the University of PennsylvaniaMurray Grossman - Hospital of the University of Pennsylvania
- Publication Details
- Brain (London, England : 1878), v 136(Pt 8), pp 2497-2509
- Publisher
- Oxford University Press
- Grant note
- R01 NS044266 / NINDS NIH HHS P01 AG032953 / NIA NIH HHS AG015116 / NIA NIH HHS AG038490 / NIA NIH HHS P01 AG017586 / NIA NIH HHS AG017586 / NIA NIH HHS R01 AG015116 / NIA NIH HHS NS053488 / NINDS NIH HHS T32 AG000255 / NIA NIH HHS HD060406 / NICHD NIH HHS NS044266 / NINDS NIH HHS P50 NS053488 / NINDS NIH HHS AG032953 / NIA NIH HHS F32 HD060406 / NICHD NIH HHS
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000322338000021
- Scopus ID
- 2-s2.0-84880939907
- Other Identifier
- 991021901314004721
InCites Highlights
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Clinical Neurology
- Neurosciences