Journal article
Comparative studies of human basophils and mast cells
Federation proceedings, v 42(8), pp 2504-2509
15 May 1983
PMID: 6301890
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Atopic disease in humans results primarily from the activity of tissue mast cells and circulating basophils. These two very similar cell types have recently been purified to near homogeneity and studies have begun to identify the biochemical mechanisms of mediator release, to explore the effects of pharmacologic manipulation of the response, and to determine unambiguously which mediators are derived from mast cells and basophils. This report will review studies examining various parameters of histamine release, the role of cyclic AMP in histamine release, and the production of arachidonic acid metabolites and their pharmacologic modulation.
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Details
- Title
- Comparative studies of human basophils and mast cells
- Creators
- D W MacGlashan, JrR P SchleimerS P PetersE S SchulmanG K AdamsA K SobotkaH H NewballL M Lichtenstein
- Publication Details
- Federation proceedings, v 42(8), pp 2504-2509
- Publisher
- United States
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pulmonary, Critical Care, and Sleep (Medicine)
- Web of Science ID
- WOS:A1983QR09500028
- Scopus ID
- 2-s2.0-0020521304
- Other Identifier
- 991014878296704721
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- Web of Science research areas
- Biology