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Comparing the yeast retrograde response and NF-κB stress responses: implications for aging
Journal article   Open access   Peer reviewed

Comparing the yeast retrograde response and NF-κB stress responses: implications for aging

Visish Srinivasan, Andres Kriete, Ahmet Sacan and S Michal Jazwinski
Aging cell, v 9(6), pp 933-941
Dec 2010
DOI: https://doi.org/10.1111/j.1474-9726.2010.00622.x
PMID: 20961379
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://europepmc.org/articles/pmc2980572View
Accepted (AM)Open Access (License Unspecified),  Open
url
https://doi.org/10.1111/j.1474-9726.2010.00622.xView
Published, Version of Record (VoR) Open

Abstract

Gene Expression Regulation, Fungal Humans Protein-Serine-Threonine Kinases - genetics NF-kappa B - metabolism Phylogeny Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae - metabolism Animals Aging - genetics NF-kappa B - genetics Chromosomes, Fungal - metabolism Models, Biological Saccharomyces cerevisiae Proteins - metabolism DNA Damage Protein-Serine-Threonine Kinases - metabolism Signal Transduction
The mitochondrial retrograde response has been extensively described in Saccharomyces cerevisiae, where it has been found to extend life span during times of mitochondrial dysfunction, damage or low nutrient levels. In yeast, the retrograde response genes (RTG) convey these stress responses to the nucleus to change the gene expression adaptively. Similarly, most classes of higher organisms have been shown to have some version of a central stress-mediating transcription factor, NF-κB. There have been several modifications along the phylogenetic tree as NF-κB has taken a larger role in managing cellular stresses. Here, we review similarities and differences in mechanisms and pathways between RTG genes in yeast and NF-κB as seen in more complex organisms. We perform a structural homology search and reveal similarities of Rtg proteins with eukaryotic transcription factors involved in development and metabolism. NF-κB shows more sophisticated functions when compared to RTG genes including participation in immune responses and induction of apoptosis under high levels of ROS-induced mitochondrial and nuclear DNA damage. Involvement of NF-κB in chromosomal stability, coregulation of mitochondrial respiration, and cross talk with the TOR (target of rapamycin) pathway points to a conserved mechanism also found in yeast.

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59 citations in Web of Science
63 citations in Scopus

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Collaboration types
Domestic collaboration
Web of Science research areas
Cell Biology
Geriatrics & Gerontology
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