Journal article
Comparison Between Real-time Intra-operative Ultrasound-based Dosimetry and CT-based Dosimetry for Prostate Brachytherapy Using Cesium-131
Technology in cancer research & treatment, v 7(6), pp 463-469
01 Dec 2008
PMID: 19044326
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The purpose of this study was to evaluate the correlation between real-time intra-operative ultrasound-based dosimetry (USD) and day 0 post-implant CT dosimetry (CTD) Cs-131 permanent prostate brachytherapy. Fifty-two consecutive patients who underwent prostate brachytherapy with Cs-131 were evaluated. Real time operating room planning was performed using VariSeed 7.1 software. Post-needle placement prostate volume was used for real-time planning. Targets for dosimetry were D-90 >110%, V-100 >90%, V-150 <50%, and V-200 <20%. The CT scan for post-operative dosimetry was obtained on day 0. The mean values for USD, CTD, and the linear correlation, respectively, were, for D-90: 114.0%, 105.61%, and 0.15; for V-100: 95.1%, 91.6%, and 0.22; for V-150: 51.5%, 46.4%, and 0.40; and for V-200: 15.8%, 17.9%, and 0.42. The differences between the mean values for USD and CTD for D-90 (p<0.01), V-100 (p<0.01), and V-150 (p<0.05) were statistically significant. For D90, 30.8% of patients had a >15% difference between USD and CTD and 51.9% of patients had a >10% difference between these values. In contrast, the USD and CTD for V-100 were within 5% in 55.8% of patients and within 10% in 86.5% of patients. This study demonstrates a correlation between the mean intra-operative USD and post-implant day 0 CTD values only for V-200. Significant variation in D-90, Viso, and V-200 values existed for individual patients between USD and CTD. These results suggest that real-time intra-operative USD does not serve as a surrogate for post-operative CTD, and that post-operative CTD is still necessary.
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Details
- Title
- Comparison Between Real-time Intra-operative Ultrasound-based Dosimetry and CT-based Dosimetry for Prostate Brachytherapy Using Cesium-131
- Creators
- Bruce L. Jacobs - University of PittsburghErin P. Gibbons - University of PittsburghRyan P. Smith - University of PittsburghSushil Beriwal - University of PittsburghKrishna Komanduri - University of PittsburghRonald M. Benoit - University of Pittsburgh
- Publication Details
- Technology in cancer research & treatment, v 7(6), pp 463-469
- Publisher
- Sage
- Number of pages
- 7
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Radiation Oncology (and Nuclear Medicine)
- Web of Science ID
- WOS:000262032200008
- Scopus ID
- 2-s2.0-57749169963
- Other Identifier
- 991021897383804721
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- Web of Science research areas
- Oncology