Journal article
Comparison of Bleeding Complications With Omega-3 Fatty Acids plus Aspirin plus Clopidogrel-Versus-Aspirin plus Clopidogrel in Patients With Cardiovascular Disease
The American journal of cardiology, v 104(8), pp 1052-1054
15 Oct 2009
PMID: 19801023
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Fish oil is used to lower triglycerides and for the secondary prevention of cardiovascular events in patients with coronary artery disease. Many of these patients will also be taking aspirin and clopidogrel. Any of these medications alone can increase the risk of bleeding; however, the risk of bleeding in patients taking all 3 of these medications has not been studied. We retrospectively reviewed the medical records for bleeding complications in 182 patients, most with coronary artery disease (mean age 61 +/- 11 years, 82% men) and being treated with high-dose fish oil (mean dose 3 +/- 1.25 g), aspirin (mean dose 161 +/- 115 mg), and clopidogrel (mean dose 75 mg), and in 182 age- and gender-matched controls treated with aspirin and clopidogrel alone. During a mean follow-up period of 33 months, 1 major bleeding episode occurred in the treatment group and no major bleeding episodes occurred in the control group (p = 1.0). During follow-up, 4 minor bleeding episodes (2.2%) occurred in the treatment group and 7 (3.9%) in the control group. More patients had minor bleeding complications in the control group than in the treatment group; however, the difference was not statistically significant (p = 0.5). In conclusion, high-dose fish oil is safe in combination with aspirin and clopidogrel and does not increase the risk of bleeding compared with that seen with aspirin and clopidogrel alone. (C) 2009 Elsevier Inc. All rights reserved. (Am J Cardiol 2009;104:1052-1054)
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Details
- Title
- Comparison of Bleeding Complications With Omega-3 Fatty Acids plus Aspirin plus Clopidogrel-Versus-Aspirin plus Clopidogrel in Patients With Cardiovascular Disease
- Creators
- Pauline D. Watson - Drexel UniversityParijat S. Joy - Drexel UniversityChileshe Nkonde - Drexel UniversityScott E. Hessen - Drexel UniversityDean G. Karalis - Drexel University
- Publication Details
- The American journal of cardiology, v 104(8), pp 1052-1054
- Publisher
- Elsevier
- Number of pages
- 3
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine
- Web of Science ID
- WOS:000270864600008
- Scopus ID
- 2-s2.0-70349485059
- Other Identifier
- 991019348821604721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Cardiac & Cardiovascular Systems