Journal article
Comparison of Endoscopic Laser Resection versus Radiation Therapy for the Treatment of Early Glottic Carcinoma
Journal of otolaryngology-head and neck surgery, v 40(3)
01 Jun 2011
PMID: 21518640
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objective: Radiation therapy (FIT) and transoral laser microsurgery (TLM) are established treatments for early glottic squamous cell carcinoma (SCC). Similar oncologic outcomes have been reported with both modalities, leading physicians to consider other factors when making clinical recommendations. One such factor is voice-related quality of life. This investigation sought to characterize differences in self-reported voice outcomes in patients undergoing RT or TLM for the treatment of Tis or T1a glottic SCC.
Methods: A retrospective cohort study was conducted of all individuals who received either RT or TLM for the treatment of Tis or T1a glottic SCC between 2004 and 2009 at the London Regional Cancer Program. The primary outcome measure was voice-related quality of life, as assessed by the Voice-Related Quality of Life questionnaire (V-RQOL). Secondary outcomes included local control, overall survival, and laryngectomy-free survival.
Results: Fifty-seven patients were eligible for this study; 34 received RT and 23 received TLM. Forty (70.2%) of the 57 patients completed the V-RQOL. No statistically significant difference in total V-RQOL score was observed between the RT and TLM cohorts (p = .228). There was, however, a trend toward higher scores (ie, less voice disability) in the physical function domain of the V-RQOL for the RT group (90.0%) compared to the TLM group (80.2%) (p = .05). No significant differences were observed in recurrence or overall survival between the two groups.
Conclusion: Both oncologic outcomes and self-rated voice-related quality of life are similar in patients treated with RT and TLM for early glottic carcinoma.
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Details
- Title
- Comparison of Endoscopic Laser Resection versus Radiation Therapy for the Treatment of Early Glottic Carcinoma
- Creators
- Heather A. Osborn - Univ Western Ontario, Schulich Sch Med & Dent, London, ON, CanadaAmanda Hu - Victoria Hosp, London Hlth Sci Ctr, Dept Otolaryngol Head & Neck Surg, London, ON N6A 5W9, CanadaVaragur Venkatesan - London Hlth Sci Ctr, Dept Radiat Oncol, London, ON, CanadaAnthony Nichols - Victoria Hosp, London Hlth Sci Ctr, Dept Otolaryngol Head & Neck Surg, London, ON N6A 5W9, CanadaJason H. Franklin - Victoria Hosp, London Hlth Sci Ctr, Dept Otolaryngol Head & Neck Surg, London, ON N6A 5W9, CanadaJohn H. Yoo - Victoria Hosp, London Hlth Sci Ctr, Dept Otolaryngol Head & Neck Surg, London, ON N6A 5W9, CanadaMercedes Ceron - Victoria Hosp, London Hlth Sci Ctr, Dept Otolaryngol Head & Neck Surg, London, ON N6A 5W9, CanadaFiona Whelan - Victoria Hosp, London Hlth Sci Ctr, Dept Otolaryngol Head & Neck Surg, London, ON N6A 5W9, CanadaKevin Fung - Victoria Hosp, London Hlth Sci Ctr, Dept Otolaryngol Head & Neck Surg, London, ON N6A 5W9, Canada
- Publication Details
- Journal of otolaryngology-head and neck surgery, v 40(3)
- Publisher
- B C Decker Inc
- Number of pages
- 5
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Otolaryngology (and Head and Neck Surgery)
- Web of Science ID
- WOS:000290637600004
- Scopus ID
- 2-s2.0-79955401257
- Other Identifier
- 991019299105404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Otorhinolaryngology