Journal article
Comparison of Plasmodium Vivax Infections in Duffy Negatives From Community and Health Center Collections in Ethiopia
Research square
03 Oct 2023
PMID: 37886593
Abstract
Malaria remains a significant cause of morbidity and mortality in Ethiopia with an estimated 4.2 million annual cases and 61% of the population living in areas at risk of malaria transmission. Throughout the country
and
are co-endemic, and Duffy expression is highly heterogeneous. The public health significance of Duffy negativity in relation to
malaria in Ethiopia, however, remains unclear.
A total of 9,580 and 4,667 subjects from community and health facilities from a malaria endemic site and an epidemic-prone site in western Ethiopia were enrolled and examined for
infection and Duffy expression. Association between Duffy expression,
and
infections were examined for samples collected from asymptomatic community volunteers and symptomatic subjects from health centers.
Among the community-based cross-sectional samples, infection rate of
among the Duffy positives was 2-22 fold higher than among the Duffy negatives. Parasite positivity rate was 10-50 fold higher in Duffy positive than Duffy negatives among samples collected from the health center settings and mixed
and
infections were significantly more common than
mono infections among Duffy negative individuals.
parasitemia measured by 18sRNA parasite gene copy number was similar between Duffy positives and Duffy negatives.
Duffy negativity does not offer complete protection against infection by
, and cases of
in Duffy negatives are widespread in Ethiopia, being found in asymptomatic volunteers from communities and in febrile patients from health centers. These findings offer evidence for consideration when developing control and intervention strategies in areas of endemic
and Duffy heterogeneity.
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Details
- Title
- Comparison of Plasmodium Vivax Infections in Duffy Negatives From Community and Health Center Collections in Ethiopia
- Creators
- Lauren Bradley - University of California, IrvineDelenasaw Yewhalaw - Jimma UniversityElizabeth Hemming-Schroeder - Colorado State UniversityBrook Jeang - University of California, IrvineMing-Chieh Lee - University of California, IrvineEndalew Zemene - Jimma UniversityTeshome Degefa - Jimma UniversityEugenia Lo - Drexel UniversityChristopher King - Case Western Reserve UniversityJames Kazura - Case Western Reserve UniversityGuiyun Yan - University of California, Irvine
- Publication Details
- Research square
- Grant note
- R01 AI162947 / NIAID NIH HHS F31 AI161887 / NIAID NIH HHS U19 AI129326 / NIAID NIH HHS D43 TW001505 / FIC NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Other Identifier
- 991022192030704721