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Comparison of difloxacin, enoxacin, and cefazolin for the treatment of experimental Staphylococcus aureus endocarditis
Journal article   Open access   Peer reviewed

Comparison of difloxacin, enoxacin, and cefazolin for the treatment of experimental Staphylococcus aureus endocarditis

J A Boscia, W D Kobasa and D Kaye
Antimicrobial agents and chemotherapy, v 32(2), pp 262-264
Feb 1988
PMID: 3163241
url
https://doi.org/10.1128/aac.32.2.262View
Published, Version of Record (VoR)Open Access (License Unspecified) Open

Abstract

Administration, Oral Animals Anti-Infective Agents - administration & dosage Anti-Infective Agents - pharmacokinetics Anti-Infective Agents - therapeutic use Cefazolin - administration & dosage Cefazolin - pharmacokinetics Cefazolin - therapeutic use Ciprofloxacin - administration & dosage Ciprofloxacin - analogs & derivatives Ciprofloxacin - pharmacokinetics Ciprofloxacin - therapeutic use Endocarditis, Bacterial - drug therapy Enoxacin Female Fluoroquinolones Half-Life Injections, Intramuscular Naphthyridines - administration & dosage Naphthyridines - pharmacokinetics Naphthyridines - therapeutic use Rabbits Staphylococcal Infections - drug therapy
This study compared difloxacin administered orally, enoxacin administered orally, and cefazolin administered intramuscularly for the treatment of experimental Staphylococcus aureus endocarditis. Difloxacin significantly reduced bacterial counts of vegetations compared with enoxacin. This study demonstrated that difloxacin was significantly more effective than enoxacin and as effective as cefazolin for the treatment of S. aureus endocarditis in rabbits.

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Web of Science research areas
Microbiology
Pharmacology & Pharmacy
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