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Comparison of intravenous dosing regimens for maintaining steady-state procainamide levels during programmed ventricular stimulation
Journal article   Peer reviewed

Comparison of intravenous dosing regimens for maintaining steady-state procainamide levels during programmed ventricular stimulation

Robert T. Brautigam, Melinda Schuster, R.Stephen Porter, Charles Nydegger and Steven P. Kutalek
The American journal of cardiology, v 70(11), pp 1087-1088
1992
PMID: 1384303

Abstract

Intravenous procainamide hydrochloride has prognostic value for drug efficacy in electrophysiologic testing in patients with sustained ventricular tachycardia 1,2 and is often used as an initial screen for drug therapy in these patients. To evaluate the effects of varying intravenous procainamide dosing regimens on providing stable plasma concentrations of the drug in the clinical electrophysiology laboratory, we compared procainamide dosing and maintenance infusions determined by population kinetics 3 with those of a standard fixed dose and maintenance infusion. 2

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Web of Science research areas
Cardiac & Cardiovascular Systems
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