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Journal article
Comparison of methods of quantifying global synovial metabolic activity with FDG-PET/CT in rheumatoid arthritis
International journal of rheumatic diseases, v 22(12), pp 2191-2198
01 Dec 2019
PMID: 31721461
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Aim 2-deoxy-2-[F-18]fluoro-d-glucose positron emission tomography/computed tomography (FDG-PET/CT) can portray increased glycolysis due to inflammation in rheumatoid arthritis (RA). The aim of this study was to evaluate and compare the reliability and construct validity of two methods of quantifying RA disease activity using FDG-PET/CT. Method Nineteen RA patients and 19 healthy controls matched to sex and age underwent prospective FDG-PET/CT imaging. Metabolic and volumetric metrics were calculated using fixed and adaptive thresholding techniques and partial volume correction. Fixed thresholds segmented regions above average maximum physiological uptake in controls. Differences of means between RA and controls were assessed using t tests, and discrimination was assessed using receiver operating characteristics. Spearman correlation analysis was used to assess associations between FDG-PET/CT measures and clinical assessments of disease activity. Results All FDG-PET/CT measures were substantially different and nearly non-overlapping between RA and controls (all P < .001). Area under the curve (AUC) for adaptive threshold parameters ranged from 0.986 to 0.997, and AUC for fixed threshold parameters ranged from 0.898 to 0.945. PET parameters were found to correlate positively with various clinical features, namely C-reactive protein, erythrocyte sedimentation rate, interleukin (IL)-6, IL-1, and swollen joint count. Conclusion All FDG-PET/CT parameters reflecting global RA disease activity differentiated between RA and controls, indicating high clinical utility to diagnose and assess RA. Adaptive thresholds can be used in a wider setting without control data, but methods utilizing fixed thresholds were more reproducible and more closely associated with indications of inflammation.
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Details
- Title
- Comparison of methods of quantifying global synovial metabolic activity with FDG-PET/CT in rheumatoid arthritis
- Creators
- William Y. Raynor - Drexel UniversityVenkata S. Jonnakuti - University of PennsylvaniaMahdi Zirakchian Zadeh - Children's Hospital of PhiladelphiaThomas J. Werner - University of PennsylvaniaGang Cheng - University of PennsylvaniaHongming Zhuang - Children's Hospital of PhiladelphiaPoul Flemming Hoilund-Carlsen - College Station Medical CenterAbass Alavi - University of PennsylvaniaJoshua F. Baker - Philadelphia VA Medical Center
- Publication Details
- International journal of rheumatic diseases, v 22(12), pp 2191-2198
- Publisher
- Wiley
- Number of pages
- 8
- Grant note
- Competitive Pilot Project Fund Award through the United States Department of Veterans Affairs (VISN4)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Radiology (Radiologic Sciences)
- Web of Science ID
- WOS:000496008200001
- Scopus ID
- 2-s2.0-85075006440
- Other Identifier
- 991019350678004721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Rheumatology