Journal article
Comparison of prenatal ultrasound and postmortem findings in fetuses with common pulmonary vein atresia
Echocardiography (Mount Kisco, N.Y.), v 36(6), pp 1153-1158
01 Jun 2019
PMID: 31116443
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background The previous literature on common pulmonary vein atresia (CPVA) mainly consists of neonatal case reports. There is a lack of research on the prenatal diagnosis of CPVA. Methods We conducted a retrospective study of all fetuses with CPVA confirmed by autopsy between August 2010 and May 2018. Prenatal echocardiographic features, autopsy findings, and genetic test results were analyzed. We compared fetal CPVA with total anomalous pulmonary venous return (TAPVR) and neonatal CPVA. Results During the study period, fetal echocardiography was performed on 31 617 fetuses. Six cases of CPVA were identified by autopsies, including 1 case performed with a cardiovascular cast. All 6 cases (100%) had asplenia syndrome (AS) and bilateral superior vena cava (BSVC). In 1 case (16.7%), the prenatal ultrasound results were in complete agreement with the postmortem findings. Four cases (66.7%) were misdiagnosed as TAPVR by prenatal echocardiography. For the remaining case (16.7%), no pulmonary venous anomalies were detected on prenatal echocardiography. No aneuploidy was identified in any of the cases. There were no statistically significant differences among the proportions of associated complex anomalies and AS between the fetal CPVA and TAPVR groups. The proportion of associated complex anomalies and AS in the fetal CPVA group was higher than that in the neonatal group (P < 0.05). Conclusions Prenatal diagnosis of fetal CPVA is difficult and challenging even for experts. Our study showed that fetal CPVA is often combined with AS, complex cardiac malformations, and BSVC. These findings may help in the diagnosis of fetal CPVA.
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Details
- Title
- Comparison of prenatal ultrasound and postmortem findings in fetuses with common pulmonary vein atresia
- Creators
- Yong Guo - Beijing Anzhen HospitalShuang Gao - Beijing Anzhen HospitalLei Kang - Dongzhimen Hospital Affiliated to Beijing University of Chinese MedicineJiancheng Han - Beijing Anzhen HospitalYe Zhang - Capital Med Univ, Beijing Anzhen Hosp, Beijing Key Lab Maternal Fetal Med Fetal Heart Di, Dept Echocardiog, 2 Anzhen Rd, Beijing 100029, Peoples R ChinaZongjie Weng - Fuzhou Maternity and Child Health Care HospitalJianfeng Shang - Beijing Anzhen HospitalXiaoyan Hao - Beijing Anzhen HospitalYing Zhao - Beijing Anzhen HospitalShuping Ge - St. Christopher's Hospital for ChildrenYihua He - Beijing Anzhen Hospital
- Publication Details
- Echocardiography (Mount Kisco, N.Y.), v 36(6), pp 1153-1158
- Publisher
- Wiley
- Number of pages
- 6
- Grant note
- BZ0308 / Beijing Key Laboratory of Maternal-Fetus Medicine in Fetal Heart Disease 2018YFC1002300 / National Key R&D Program of China Z181100001918008 / Beijing Municipal Science & Technology Commission
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000471831300017
- Scopus ID
- 2-s2.0-85066914498
- Other Identifier
- 991019167550104721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Cardiac & Cardiovascular Systems