Journal article
Comparison of the retention behavior of β-blockers using immobilized artificial membrane chromatography and lysophospholipid micellar electrokinetic chromatography
Journal of Chromatography A, v 810(1), pp 95-103
1998
PMID: 9691294
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
We have demonstrated that significant differences exist between the retention of eight β-blockers analyzed with immobilized artificial membrane (IAM) and lysophospholipid micellar electrokinetic capillary (LMEKC) chromatographic methods. The general retention trends are maintained with highly hydrophilic compounds such as atenolol eluting first and more hydrophobic compounds such as propranolol eluting last. The retention order, however, is different and would result in major ranking differences. LMEKC demonstrates a better correlation with liposomal partitioning (R2=0.95) than does IAM chromatography (
R2=0.60). LMEKC, with its higher efficiency, can allow a more specific evaluation of lipophilicity than IAM chromatography and is useful in the analysis of pharmaceutical candidates, particularly for ranking purposes.
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Details
- Title
- Comparison of the retention behavior of β-blockers using immobilized artificial membrane chromatography and lysophospholipid micellar electrokinetic chromatography
- Creators
- John A Masucci - Johnson & Johnson (United States)Gary W Caldwell - Johnson & Johnson (United States)Joe P Foley - Villanova University
- Publication Details
- Journal of Chromatography A, v 810(1), pp 95-103
- Publisher
- Elsevier
- Number of pages
- 9
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Chemistry
- Web of Science ID
- WOS:000074443300010
- Scopus ID
- 2-s2.0-0031837142
- Other Identifier
- 991014877691304721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- Web of Science research areas
- Biochemical Research Methods
- Chemistry, Analytical