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To compare societal values across three health-state classification systems in older African Americans with depression and to describe the association of these instruments to depression severity.
We summarized baseline values for EQ-5D (US weights) and HUI2/3 (Canadian weights) and their subscales for 118 older African American participants enrolled in a randomized depression treatment trial and calculated correlations between the different instruments. We evaluated ceiling and floor effects for each instrument by comparing the proportion at the highest and lowest possible score for each tool. Also, utility scores were assessed by level of depression severity (mild, moderate, moderate severe, severe) scores as measured by the Patient Health Questionnaire (PHQ-9).
Mean utility values were 0.58 (SD = 0.21) for EQ-5D, 0.52 (SD = 0.21) for HUI2, and 0.36 (SD = 0.31) for HUI3. For the EQ-5D, 72 % of participants reported having some problems on the anxiety/depression domain. On the emotion domain for the HUI2, 23 % reported the highest level of impairment compared to only 3 % on the HUI3. No participant scored at the floor for the EQ-5D, HUI2, or HUI3 index; one participant scored at the ceiling value on the HUI3 index. Correlations ranged from 0.63 to 0.82 (all of which were significant at an alpha level of 0.05). In general, utility scores trended inversely with depression level.
Small differences in the three preference-weighted health-state classification systems were evident for this sample of older African Americans with depressive symptoms, with HUI scores lower than EQ-5D. For this sample, utility scores were lower (i.e., poorer) than the general United States population with depression on each utility measure.
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Details
Title
Comparison of three societally derived health-state classification values among older African Americans with depressive symptoms
Creators
Eric Jutkowitz - University of Minnesota
Laura Pizzi - Jefferson School of Pharmacy
Edward Hess - Johns Hopkins University
Dong-Churl Suh - Chung-Ang University
Laura N. Gitlin - Johns Hopkins Medicine
Publication Details
Quality of life research, v 22(6), pp 1491-1498
Publisher
Springer Nature
Number of pages
8
Grant note
RC1MH090770 / NATIONAL INSTITUTE OF MENTAL HEALTH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH)
RO1 MH 079814; R24 MH074779; RC1MH090770 / National Institute of Mental Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH)
Resource Type
Journal article
Language
English
Academic Unit
College of Nursing and Health Professions; Drexel University
Web of Science ID
WOS:000322735700035
Scopus ID
2-s2.0-84885187739
Other Identifier
991020111973104721
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