Journal article
Compendium of fractionation choices for gynecologic HDR brachytherapy—An American Brachytherapy Society Task Group Report
Brachytherapy, v 18(4), pp 429-436
Jul 2019
PMID: 30979631
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The purpose of this study was to report a list of accepted fractionation schemes for high-dose-rate (HDR) brachytherapy for gynecological cancers in a definitive, neoadjuvant, or adjuvant setting.
Members of the American Brachytherapy Society (ABS) Task Force with expertise in gynecological brachytherapy reviewed the literature and existing ABS guidelines regarding various dose-fractionation schedules for HDR brachytherapy to create this compendium. Other resources include current guidelines published by medical societies, clinical trials, the published medical literature, and the clinical experience of the ABS Task Force members. The ABS consensus statements for HDR brachytherapy practice were reviewed for these fractionation schemes and form the major source for this report. Specific recommendations for therapy and recommendations for further investigations were made when there was agreement.
A variety of dose-fractionation schedules for HDR brachytherapy alone or integrating brachytherapy with external-beam radiation exist. The choice of a given fractionation schedule may be appropriate depending on the practice situation for the patient and the resources available. While there is no single optimal dose-fractionation scheme for any disease site or clinical situation, higher doses per fraction with fewer fractions per regimen have been known to increase toxicity. The corresponding 2-Gray (Gy) per fraction radiobiologic equivalent doses have been provided (normalized therapy dose) to compare the various regimens where indicated and can be used to estimate isoeffective schedules.
This compendium of HDR brachytherapy fractionation schedules provides various options to the gynecologic brachytherapist and a ready reference for clinical use in the management of gynecological cancer treatments.
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Details
- Title
- Compendium of fractionation choices for gynecologic HDR brachytherapy—An American Brachytherapy Society Task Group Report
- Creators
- Kevin Albuquerque - The University of Texas Southwestern Medical CenterBrian A. Hrycushko - The University of Texas Southwestern Medical CenterMatthew M. Harkenrider - Loyola University ChicagoJyoti Mayadev - University of California, San DiegoAnn Klopp - The University of Texas MD Anderson Cancer CenterSushil Beriwal - University of PittsburghDaniel G. Petereit - Rapid City Regional HospitalDaniel J. Scanderbeg - University of California, San DiegoCatherine Yashar - University of California, San Diego
- Publication Details
- Brachytherapy, v 18(4), pp 429-436
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Radiation Oncology (and Nuclear Medicine)
- Web of Science ID
- WOS:000476854200001
- Scopus ID
- 2-s2.0-85063999293
- Other Identifier
- 991021897264204721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Oncology
- Radiology, Nuclear Medicine & Medical Imaging