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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Competitive inhibitor of cellular α-glucosidases protects mice from lethal dengue virus infection
Antiviral research, v 92(2), pp 369-371
Nov 2011
PMID: 21854808
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Dengue virus infection causes diseases in people, ranging from the acute febrile illness dengue fever, to life-threatening dengue hemorrhagic fever/dengue shock syndrome. We previously reported that a host cellular α-glucosidases I and II inhibitor, imino sugar CM-10-18, potently inhibited dengue virus replication in cultured cells, and significantly reduced viremia in dengue virus infected AG129 mice. In this report we show that CM-10-18 also significantly protects mice from death and/or disease progress in two mouse models of lethal dengue virus infection. Our results thus provide a strong support for the development of CM-10-18 or its derivatives as antiviral agents to treat servere dengue virus infections.
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Details
- Title
- Competitive inhibitor of cellular α-glucosidases protects mice from lethal dengue virus infection
- Creators
- Jinhong Chang - Drexel UniversityWouter Schul - Novartis Institute for Tropical DiseasesAndy Yip - Novartis Institute for Tropical DiseasesXiaodong Xu - Hepatitis B FoundationJu-Tao Guo - Drexel UniversityTimothy M Block - Drexel University
- Publication Details
- Antiviral research, v 92(2), pp 369-371
- Publisher
- Elsevier
- Grant note
- R43 AI084267-01 / NIAID NIH HHS AI061441 / NIAID NIH HHS AI084267-0109 / NIAID NIH HHS U01 AI061441 / NIAID NIH HHS U01 AI061441-01 / NIAID NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000297427200028
- Scopus ID
- 2-s2.0-80054858136
- Other Identifier
- 991019168295304721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Pharmacology & Pharmacy
- Virology