Journal article
Complementary Roles of Orexin and Melanin-Concentrating Hormone in Feeding Behavior
International journal of endocrinology, v 2013, pp 1-10
2013
PMID: 23935621
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Transcribed within the lateral hypothalamus, the neuropeptides orexin/hypocretin (OX) and melanin-concentrating hormone (MCH) both promote palatable food intake and are stimulated by palatable food. While these two neuropeptides share this similar positive relationship with food, recent evidence suggests that this occurs through different albeit complementary effects on behavior, with OX promoting food seeking and motivation for palatable food and MCH functioning during ongoing food intake, reinforcing the consumption of calorically dense foods. Further differences are evident in their effects on physiological processes, which are largely opposite in nature. For example, activation of OX receptors, which is neuronally excitatory, promotes waking, increases energy expenditure, and enhances limbic dopamine levels and reward. In contrast, activation of MCH receptors, which is neuronally inhibitory, promotes paradoxical sleep, enhances energy conservation, reduces limbic dopamine, and increases depressive behavior. This review describes these different effects of the neuropeptides, developing the hypothesis that they stimulate the consumption of palatable food through excessive seeking in the case of OX and through excessive energy conservation in the case of MCH. It proposes that OX initiates food intake and subsequently stimulates MCH which then acts to prolong the consumption of palatable, energy-dense food.
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Details
- Title
- Complementary Roles of Orexin and Melanin-Concentrating Hormone in Feeding Behavior
- Creators
- Jessica R. Barson - Rockefeller UniversityIrene Morganstern - Rockefeller UniversitySarah F. Leibowitz - Rockefeller University
- Publication Details
- International journal of endocrinology, v 2013, pp 1-10
- Publisher
- Wiley
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy; College of Medicine; Drexel University
- Web of Science ID
- WOS:000322339200001
- Scopus ID
- 2-s2.0-84880891869
- Other Identifier
- 991020099678104721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Endocrinology & Metabolism