Journal article
Complete ablation of the 14-3-3epsilon protein results in multiple defects in neuropsychiatric behaviors
Behavioural brain research, v 319, pp 31-36
15 Feb 2017
PMID: 27845227
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
•The Ywhae homozygous knockout mice had a lower body weight than the wild-type mice.•The complete 14-3-3epsilon deficiency caused increased locomotor activity.•Ywhae homozygous deficient mice showed deficits in cognition.•14-3-3epsilon ablation resulted in increased sociability.
Previous studies show that mice with Ywhae deficiency show abnormalities in brain development including defects in neuronal migration of post-mitotic pyramidal neurons as well as neuronal differentiation and proliferation in neuronal progenitor cells. Also, our previous research indicated that the Ywhae knockout mice show moderate defects in working memory and anxiety-like behavior. This previous work was performed using heterozygous mutant mice. Here we performed behavioral analyses using homozygous Ywhae knockout mice and found that the homozygous Ywhae knockout mice have increased locomotor activity, decreased working memory, and increased sociability. Taken together with the results obtained from the previous pathophysiological analyses in the Ywhae knockout mice, the Ywhae knockout mouse is useful for pathophysiological analyses of neuropsychiatric disorders caused by defects during neurodevelopment.
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Details
- Title
- Complete ablation of the 14-3-3epsilon protein results in multiple defects in neuropsychiatric behaviors
- Creators
- Tomoka Wachi - Drexel UniversityBrett Cornell - Drexel UniversityKazuhito Toyo-oka - Drexel University
- Publication Details
- Behavioural brain research, v 319, pp 31-36
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000392558300005
- Scopus ID
- 2-s2.0-84995772571
- Other Identifier
- 991019168015804721
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- Collaboration types
- International collaboration
- Web of Science research areas
- Behavioral Sciences
- Neurosciences