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Journal article
Complete wound closure following a single topical application of a novel autologous homologous skin construct: first evaluation in an open-label, single-arm feasibility study in diabetic foot ulcers
International wound journal, v 17(5), pp 1366-1375
Oct 2020
PMID: 32453512
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Diabetic foot ulcers (DFUs) are a growing burden on patients and health care systems that often require multiple treatments of both conventional and advanced modalities to achieve complete wound closure. A novel autologous homologous skin construct (AHSC) has been developed to treat cutaneous defects with a single topical application, by leveraging the endogenous repair capabilities of the patient's healthy skin. The AHSC's ability to close DFUs with a single treatment was evaluated in an open-label, single-arm feasibility study. Eleven patients with DFUs extending up to tendon, bone, or capsule received a single topical application of AHSC. Closure was documented weekly with high-resolution digital photography and wound planimetry. All 11 DFUs demonstrated successful graft take. Ten DFUs closed within 8 weeks. The median time-to-complete closure was 25 days. The mean percent area reduction for all 11 wounds at 4 weeks was 83%. There were no adverse events related to the AHSC treatment site. This pilot study demonstrated AHSC may be a viable single application topical intervention for DFUs and warrants investigation in larger, controlled studies.
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Details
- Title
- Complete wound closure following a single topical application of a novel autologous homologous skin construct: first evaluation in an open-label, single-arm feasibility study in diabetic foot ulcers
- Creators
- David G Armstrong - University of Southern CaliforniaDennis P Orgill - Brigham and Women's HospitalRobert Galiano - Northwestern UniversityPaul M Glat - Drexel UniversityMarissa Carter - Strategic Solutions, Inc., Cody, Wyoming, USA.Charles M Zelen - Professional Education and Research InstituteWilliam W Li - Angiogenesis Foundation
- Publication Details
- International wound journal, v 17(5), pp 1366-1375
- Publisher
- Wiley
- Grant note
- Grant001 / PolarityTE UL1 TR001855 / NCATS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000535318100001
- Scopus ID
- 2-s2.0-85085575772
- Other Identifier
- 991019167884104721
UN Sustainable Development Goals (SDGs)
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Dermatology
- Surgery