Journal article
Completion of intraperitoneal chemotherapy in advanced ovarian cancer and catheter-related complications
Gynecologic oncology, v 116(3), pp 345-350
01 Mar 2010
PMID: 19959211
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objective. Combination intravenous/intraperitoneal (IV/IP) chemotherapy has been shown in three randomized trials to be superior to IV therapy alone in the treatment of advanced ovarian cancer with respect to overall survival (OS). We Sought to evaluate the effect of dose modification of IP therapy oil completion rates.
Methods, From November 1999 until August 2008, all optimally debulked, advanced stage ovarian cancer patients who received adjuvant IP chemotherapy at a single institution were reviewed. The primary endpoint was completion of 6 cycles of IP chemotherapy. This rate was compared to published results from COG 172. A secondary analysis evaluated completion of chemotherapy based on IP catheter type. Statistical,analysis was performed with a chi square test with a significance level of p < 0.05.
Results. One hundred and three patients received IP chemotherapy during this; period. Seventy-five patients received the modified IV/IP chemotherapy regimen. Sixty-two patients (83%) completed all 6 cycles in Our cohort compared to 119 patients (42%) reported in GOG 172 (p = 0.0001). Fifty-five patients had a fenestrated catheter (F) and 48 had a non-fenestrated (NF) catheter. Eight patients in each cohort discontinued treatment, for a completion rate of 85.5% in NF and 82.3% in F (p = 0.79).
Conclusions. The dose modifications utilized in this study allowed for completion of 6 cycles of adjuvant IP chemotherapy in 83% of patients. Choice of catheter type did not affect completion rates. Continued monitoring Of Outcomes is planned to compare PFS and OS. The high completion rate may increase acceptance of IP chemotherapy in the community setting. (C) 2009 Elsevier Inc. All rights reserved.
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Details
- Title
- Completion of intraperitoneal chemotherapy in advanced ovarian cancer and catheter-related complications
- Creators
- Jamie L. Lesnock - Magee-Womens HospitalScott D. Richard - University of PittsburghKristin K. Zorn - University of PittsburghThomas C. Krivak - University of PittsburghSushil Beriwal - University of PittsburghPaniti Sukumvanich - University of PittsburghWilliam C. McBee - University of PittsburghJoseph L. Kelley - University of PittsburghRobert P. Edwards - University of Pittsburgh
- Publication Details
- Gynecologic oncology, v 116(3), pp 345-350
- Publisher
- Elsevier
- Number of pages
- 6
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Radiation Oncology (and Nuclear Medicine); Obstetrics and Gynecology
- Web of Science ID
- WOS:000275360000013
- Scopus ID
- 2-s2.0-75749134463
- Other Identifier
- 991021897376804721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Obstetrics & Gynecology
- Oncology