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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Complex regional pain syndrome - phenotypic characteristics and potential biomarkers
Nature reviews. Neurology, v 14(5), pp 272-284
May 2018
PMID: 29545626
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Complex regional pain syndrome (CRPS) is a pain condition that usually affects a single limb, often following an injury. The underlying pathophysiology seems to be complex and probably varies between patients. Clinical diagnosis is based on internationally agreed-upon criteria, which consider the reported symptoms, presence of signs and exclusion of alternative causes. Research into CRPS biomarkers to support patient stratification and improve diagnostic certainty is an important scientific focus, and recent progress in this area provides an opportunity for an up-to-date topical review of measurable disease-predictive, diagnostic and prognostic parameters. Clinical and biochemical attributes of CRPS that may aid diagnosis and determination of appropriate treatment are delineated. Findings that predict the development of CRPS and support the diagnosis include trauma-related factors, neurocognitive peculiarities, psychological markers, and local and systemic changes that indicate activation of the immune system. Analysis of signatures of non-coding microRNAs that could predict the treatment response represents a new line of research. Results from the past 5 years of CRPS research indicate that a single marker for CRPS will probably never be found; however, a range of biomarkers might assist in clinical diagnosis and guide prognosis and treatment.
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Details
- Title
- Complex regional pain syndrome - phenotypic characteristics and potential biomarkers
- Creators
- Frank Birklein - University Medical Center of the Johannes Gutenberg University MainzSeena K Ajit - Drexel UniversityAndreas Goebel - University of LiverpoolRoberto S G M Perez - Amsterdam UMC Location VUmcClaudia Sommer - University of Würzburg
- Publication Details
- Nature reviews. Neurology, v 14(5), pp 272-284
- Publisher
- Springer Nature
- Grant note
- R21 NS082991 / NINDS NIH HHS R01 NS102836 / NINDS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000431066800010
- Scopus ID
- 2-s2.0-85045960888
- Other Identifier
- 991019167934004721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Clinical Neurology