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Compound release from core–shell carriers triggered by oscillating fields: Monte Carlo simulations
Journal article   Peer reviewed

Compound release from core–shell carriers triggered by oscillating fields: Monte Carlo simulations

Nily Dan
Colloids and surfaces. A, Physicochemical and engineering aspects, v 481
20 Sep 2015
DOI: https://doi.org/10.1016/j.colsurfa.2015.04.048
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

Controlled release Drug release Fickian diffusion Oscillating fields
•Simulate the release of encapsulated compounds under oscillating fields.•Release rate approaches the permanently permeable system in high-frequency fields.•Molecular re-arrangement in the core enhances the release rate significantly. Oscillating fields such as electrostatic or ultrasound are frequently used to induce release from nano and microcapsule carriers, but the effect of the field frequency has not been examined to date. This paper presents the results of Monte Carlo simulations for the release rate of encapsulated compounds from core–shell microcapsules subjected to an oscillating field. We find that the release rate approaches that of the permanently permeable case when the oscillation frequency is relatively high, even if the fraction of time the shell is permeable is 50% or less. Examination of the distribution of encapsulated molecules in the core shows that they rearrange during the impermeable part of the cycle, thereby enriching the shell/solution boundary and increasing the driving force for release in the next permeable part of the cycle.

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4 citations in Web of Science
4 citations in Scopus

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Web of Science research areas
Chemistry, Physical
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