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Published, Version of Record (VoR)CC BY V4.0, Open
Journal article
Computational modeling of brainstem circuits controlling locomotor frequency and gait
eLife, v 8
21 Jan 2019
PMID: 30663578
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
A series of recent studies identified key structures in the mesencephalic locomotor region and the caudal brainstem of mice involved in the initiation and control of slow (exploratory) and fast (escape-type) locomotion and gait. However, the interactions of these brainstem centers with each other and with the spinal locomotor circuits are poorly understood. Previously we suggested that commissural and long propriospinal interneurons are the main targets for brainstem inputs adjusting gait (Danner et al., 2017). Here, by extending our previous model, we propose a connectome of the brainstem-spinal circuitry and suggest a mechanistic explanation of the operation of brainstem structures and their roles in controlling speed and gait. We suggest that brainstem control of locomotion is mediated by two pathways, one controlling locomotor speed via connections to rhythm generating circuits in the spinal cord and the other providing gait control by targeting commissural and long propriospinal interneurons.
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Details
- Title
- Computational modeling of brainstem circuits controlling locomotor frequency and gait
- Creators
- Jessica Ausborn - Drexel UniversityNatalia A. Shevtsova - Drexel UniversityVittorio Caggiano - IBMSimon M. Danner - Drexel UniversityIlya A. Rybak - Drexel University
- Publication Details
- eLife, v 8
- Publisher
- Elife Sciences Publications Ltd
- Number of pages
- 19
- Grant note
- R01NS095366; R01NS090919 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA College of Medicine, Drexel University Edward Jekkal Muscular Dystrophy Association Fellowship R01NS095366 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000457387900001
- Scopus ID
- 2-s2.0-85060904145
- Other Identifier
- 991019169465804721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- Web of Science research areas
- Biology