Journal article
Computational modeling of spinal circuits controlling limb coordination and gaits in quadrupeds
eLife, v 6
22 Nov 2017
PMID: 29165245
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Interactions between cervical and lumbar spinal circuits are mediated by long propriospinal neurons (LPNs). Ablation of descending LPNs in mice disturbs left-right coordination at high speeds without affecting fore-hind alternation. We developed a computational model of spinal circuits consisting of four rhythm generators coupled by commissural interneurons (CINs), providing left-right interactions, and LPNs, mediating homolateral and diagonal interactions. The proposed CIN and diagonal LPN connections contribute to speed-dependent gait transition from walk, to trot, and then to gallop and bound; the homolateral LPN connections ensure fore-hind alternation in all gaits. The model reproduces speed-dependent gait expression in intact and genetically transformed mice and the disruption of hindlimb coordination following ablation of descending LPNs. Inputs to CINs and LPNs can affect interlimb coordination and change gait independent of speed. We suggest that these interneurons represent the main targets for supraspinal and sensory afferent signals adjusting gait.
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Details
- Title
- Computational modeling of spinal circuits controlling limb coordination and gaits in quadrupeds
- Creators
- Simon M. Danner - Drexel UniversityNatalia A. Shevtsova - Drexel UniversityAlain Frigon - Univ Sherbrooke, Dept Pharmacol Physiol, Sherbrooke, PQ, CanadaIlya A. Rybak - Drexel University
- Publication Details
- eLife, v 6
- Publisher
- Elife Sciences Publications Ltd
- Number of pages
- 25
- Grant note
- R01NS090919 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) R01 NS081713; R01 NS090919; R01 NS095366 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000417870000001
- Scopus ID
- 2-s2.0-85041060867
- Other Identifier
- 991019167874104721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biology