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Journal article
Computerized tomography measured liver fat is associated with low levels of N-terminal pro-brain natriuretic protein (NT-proBNP). Multi-Ethnic Study of Atherosclerosis
Metabolism, clinical and experimental, v 65(5), pp 728-735
01 May 2016
PMID: 27085779
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
N-terminal pro B-type natriuretic peptide (NT-proBNP) is inversely associated with diabetes mellitus, obesity and metabolic syndrome. We aim to characterize the association between NT-proBNP and nonalcoholic fatty liver disease (NAFLD), a condition strongly associated with metabolic syndrome.
4529 participants from the Multi-Ethnic Study of Atherosclerosis (MESA) free of cardiovascular disease, without self-reported liver disease and not diabetic at their baseline visit in 2000–2002 were included in this analysis. NAFLD was defined by a liver attenuation <40 HU. Relative prevalence (RP) for NAFLD was assessed adjusted for age, race, and sex, percentage of dietary calories derived from fat, total intentional exercise, alcoholic drinks per week, and interleukin-6 by quintiles of NT-proBNP. Adjusted linear spline model was used to characterize a non-linear association between NT-proBNP and liver fat. The inflection point (IP) was the NT-proBNP concentration where there was a change in slope in the association between liver attenuation and NT-proBNP.
RP for NAFLD decreased by 30% from the lowest to the highest quintile of NT-proBNP, p=0.01. We observed an inverse linear association between NT-proBNP and liver fat, which plateaued (IP) at an NT-proBNP concentration of 45pg/mL. Linear regression coefficient (SE) per unit of NT-proBNP less than and greater than or equal to IP was of 0.05 (0.02), p=0.001 and 0.0006 (0.0008), p=0.5, respectively; differences between slopes, p<0.0001.
In this cross-sectional study of a community based multiethnic sample of non-diabetic adults, low levels of NT-proBNP are associated with greater prevalence of NAFLD.
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- Title
- Computerized tomography measured liver fat is associated with low levels of N-terminal pro-brain natriuretic protein (NT-proBNP). Multi-Ethnic Study of Atherosclerosis
- Creators
- Otto A. Sanchez - University of MinnesotaMariana Lazo-Elizondo - Johns Hopkins MedicineIrfan Zeb - Roosevelt HospitalRussell P. Tracy - University of VermontRyan Bradley - National University of Natural MedicineDaniel A. Duprez - University of MinnesotaHossein Bahrami - Cardiovascular Institute of the SouthCarmen A. Peralta - University of California, San FranciscoLori B. Daniels - University of California San DiegoJoão A. Lima - Johns Hopkins Bayview Medical CenterAlan Maisel - University of California San DiegoDavid R. Jacobs - University of MinnesotaMathew J. Budoff - UCLA Medical Center
- Publication Details
- Metabolism, clinical and experimental, v 65(5), pp 728-735
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative
- Web of Science ID
- WOS:000374714000011
- Scopus ID
- 2-s2.0-84959314864
- Other Identifier
- 991020550347104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Endocrinology & Metabolism